Empirical evidence accumulated over many decades revealed an apparent contradiction between the health and survival of men and women. Women enjoy a longer life than men in all countries of the world, but women tend to report poorer self-rated health, they have higher disability levels at all ages and perform more poorly on physical tests than men. This so-called male-female health-survival paradox has far-reaching economic, sociological, and medical implications for human societies. We have spent the past five years investigating the health-survival paradox using an exceptionally rich data resource of Danish register and survey data (Oksuzyan et al., 2008, 2009, 2010a, 2011, 2013; Jacobsen et al. 2008). Generally, we have not been able to confirm any major impact of many of the suggested underlying mechanisms such as male underreporting of health problems and medication use (Oksuzyan et al., 2009). We also performed cross- national comparisons with other high-income countries (Japan and US) and found consistent sex differentials in survival and health (Oksuzyan et al., 2010b). Finally, we extended our analyses to the Utah population and found that, despite high female fertility and a healthy male life style (low tobacco and alcohol consumption), females in Utah have very substantial survival advantages (Lindahl-Jacobsen et al., 2013). In this renewal we intend to expand this research to test how universal are the sex differences in health and survival in populations that experience living conditions and cultures very different from contemporary Western societies (China and Russia). In these studies we will focus on the same theme as in the primate study, namely social status and how it contributes to male-female differences in health and survival and compare them to the rich data available in Denmark. Furthermore, we intend to use the comprehensive cause of death data available in Denmark and Utah to test how male-female differences in causes of death may contribute to the paradox. By focusing on the outstanding, already existing human data resources that were created in our previous P01 work and also used in project 1, and by making explicit cross-species comparisons between our study population and the primate population that will be examined in Project 3, we propose to shed new light on potential mechanisms underlying the male-female health-survival paradox.

Public Health Relevance

Women have longer life expectancy than men in all countries of the world, but they tend to report poorer self- rated health and have higher disability levels. We have collected human and primate data to provide insight into the potential universality of this male-female health-survival paradox with a special emphasis on the importance of social position as well as underlying human diseases assessed on the basis of causes of death.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG031719-10
Application #
9922226
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
10
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Zhao, Xin; Liu, Xiaomin; Zhang, Aiping et al. (2018) The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. Aging (Albany NY) 10:1206-1222
Gesquiere, Laurence R; Pugh, Mya; Alberts, Susan C et al. (2018) Estimation of energetic condition in wild baboons using fecal thyroid hormone determination. Gen Comp Endocrinol 260:9-17
Höhn, Andreas; Larsen, Lisbeth Aagaard; Schneider, Daniel Christoph et al. (2018) Sex differences in the 1-year risk of dying following all-cause and cause-specific hospital admission after age 50 in comparison with a general and non-hospitalised population: a register-based cohort study of the Danish population. BMJ Open 8:e021813
Santacroce, Adriana; Wastesson, Jonas W; Höhn, Andreas et al. (2018) Gender differences in the use of anti-infective medications before and after widowhood: a register-based study. J Epidemiol Community Health 72:526-531
Alberts, Susan C (2018) Social influences on survival and reproduction: Insights from a long-term study of wild baboons. J Anim Ecol :
Oksuzyan, Anna; Sauer, Torsten; Gampe, Jutta et al. (2018) Is Who you Ask Important? Concordance Between Survey and Registry Data on Medication Use Among Self- and Proxy-Respondents in the Longitudinal Study of Aging Danish Twins and the Danish 1905-Cohort Study. J Gerontol A Biol Sci Med Sci :
Gesquiere, Laurence R; Altmann, Jeanne; Archie, Elizabeth A et al. (2018) Interbirth intervals in wild baboons: Environmental predictors and hormonal correlates. Am J Phys Anthropol 166:107-126
Zarulli, Virginia; Barthold Jones, Julia A; Oksuzyan, Anna et al. (2018) Women live longer than men even during severe famines and epidemics. Proc Natl Acad Sci U S A 115:E832-E840
Oksuzyan, Anna; Singh, Prashant Kumar; Christensen, Kaare et al. (2018) A Cross-National Study of the Gender Gap in Health Among Older Adults in India and China: Similarities and Disparities. Gerontologist 58:1156-1165
Zeng, Yi; Nie, Chao; Min, Junxia et al. (2018) Sex Differences in Genetic Associations With Longevity. JAMA Netw Open 1:

Showing the most recent 10 out of 130 publications