The Administrative Core A of this Program Project is designed to provide scientific leadership and mentoring to trainees, effective communication, and an administrative support structure to ensure the coordination of all Program Project activities. The essential services provided by the Core include: administrative support for all project and core leaders; fiscal management and oversight for all components of the Program Project; and organization and communication of all Program Project meetings and activities. The overall goal of this Core is to provide effective and efficient leadership of the P01. The roles of the Core Leaders and administrative staff are to facilitate communication while stimulating scientific and technological interactions between the Projects, Cores and the associated staff and trainees. In order to achieve this goal, the Core has established three Aims:
Aim 1 : Establish and maintain an administrative structure to provide support for and management of all Program Project activities. Leadership will be provided by the Program PI (Dr. Berger) and Co-PI (Dr. Marmorstein) with input from the Executive Committee (Drs. Berger, Marmorstein, Adams, Zhang, Noma, Garcia, Lan and Schultz). Oversight of the program will also be provided by face-to-face Internal and External Scientific Advisory Board meetings on years 2 and 4 of the grant cycle. An Administrative Assistant (Sophia Castro, 50 % effort) will aid in communication among members of the projects, communication with Internal and External Scientific Advisory Boards and in coordinating fiscal management and timely grant reporting.
Aim 2 : Foster an environment to maximize collaborative research among Program Project investigators and between other P01 and NIA initiatives. This will be facilitated by Program Project Meetings every third week involving the Program Leaders, their trainees working on the project, and Core staff, with one group or Core presenting per meeting on a rotating basis. We will also have Program Project Retreats on years 1 and 3 of the grant cycle involving the Program Leaders and members of their respective groups and Cores to present talks and posters and interact at an off-site location. The PI will also advocate for space, personnel and resources for the Program Project and communicate with the NIA.
Aim 3. Ensure compliance with all institutional, governmental and NIA regulations and policies. The PI will ensure compliance with animal research and ensure that the outlined Data Sharing Plan is followed.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG031862-11
Application #
9491061
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2018-08-15
Budget End
2019-06-30
Support Year
11
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Ray-Gallet, Dominique; Ricketts, M Daniel; Sato, Yukari et al. (2018) Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit. Nat Commun 9:3103
Lin-Shiao, Enrique; Lan, Yemin; Coradin, Mariel et al. (2018) KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis. Genes Dev 32:181-193
Dou, Zhixun; Berger, Shelley L (2018) Senescence Elicits Stemness: A Surprising Mechanism for Cancer Relapse. Cell Metab 27:710-711
Berson, Amit; Sartoris, Ashley; Nativio, Raffaella et al. (2017) TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling. Curr Biol 27:3579-3590.e6
Bonini, Nancy M; Berger, Shelley L (2017) The Sustained Impact of Model Organisms-in Genetics and Epigenetics. Genetics 205:1-4
Dou, Zhixun; Ghosh, Kanad; Vizioli, Maria Grazia et al. (2017) Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature 550:402-406
Mews, Philipp; Donahue, Greg; Drake, Adam M et al. (2017) Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory. Nature 546:381-386
Yang, Ting-Lin B; Chen, Qijun; Deng, Jennifer T et al. (2017) Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche. Nat Commun 8:14766
Cole, John J; Robertson, Neil A; Rather, Mohammed Iqbal et al. (2017) Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions. Genome Biol 18:58
Feng, Zijie; Wang, Lei; Sun, Yanmei et al. (2017) Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase. Cancer Res 77:401-411

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