The main function of the Bone Stem Cell Core (Core C) is to isolate and distribute bone marrow- derived mesenchymal stem/progenitor cells (BMSCs) to the investigators of the individual projects, and to provide technical support for use of the cells. A key component essential to the success of the proposed Program Project is the availability of BMSCs because all projects require these cells. Thus, a centralized Core facility for the production of quality cells is crucial to the success of this dynamically coordinated Program Project. This Core will benefit the research efforts of individual investigator by reducing costs, providing quality control for study procedures, and enhancing collaborations among multiple disciplines to achieve greater scientific gain through an integrated approach. In addition, production and distribution of cells from a centralized facility will ensure that all studies start with cells of the same lineages and background.
The Specific Aims are: 1. Isolate, characterize and distribute mouse BMSCs, human bone marrow MSCs (hMSCs), and 2. Provide ongoing technical support for hypoxic and conventional MSC culture and differentiation (osteogenic, adipogenic, and chondrogenic) assays. By achieving these objectives, this Core will function as a unique resource to provide mouse and human BMSCs and technical assistance to the individual projects, as well as to other Georgia Regents University investigators who are interested in studies related to aging, metabolic bone diseases, or stem cell research.

Public Health Relevance

The main purpose of the Bone Stem Cell Core (Core C) is to generate mouse and human bone marrow- derived mesenchymal stem cells (BMSCs) for the Program Project, and provide advice to individual projects in using these cells. The Core C is essential for the success of the Program Project as all individual projects in the Program will need to use the same cells in order for the data sets generated from individual projects are comparable, consistent and synergistic.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG036675-07
Application #
9471310
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
7
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Augusta University
Department
Type
DUNS #
City
Augusta
State
GA
Country
United States
Zip Code
30912
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