Core B: The HAALSI program comprises four subprojects that focus on 1) physical and cognitive functioning;2)cardiometabolic risks;3) aging with HIV;and 4) economic well-being and productivity. The program links new longitudinal surveys among respondents ages 50 years and older in three INDEPTH sites (Agincourt, Ifakara and Navrongo) with the long-running health and demographic surveillance systems (HDSS) already in place in those sites. A central requirement in all four subprojects is valid information on mortality by age and cause. The Mortality Core (Core B) will leverage existing infrastructure within the HDSS sites to monitor mortality and migration and use this to inform the longitudinal surveys conducted through this program. The Mortality Core will assist all subprojects by providing accurate, consistent, comparable measures of all-cause and cause-specific mortality and assure that migration is appropriately addressed to provide a full accounting ofthe study cohorts. The Core will develop standardized data definitions and data extraction procedures that can be used by all participating sites to produce the required indicators from their routine longitudinal health and demographic surveillance. In addition, monitoring ofthe study cohorts will require new methods and procedures to account for the study populations at each site and minimize loss to follow-up of the program cohorts. The Mortality Core has three specific aims: 1. Measure all-cause mortality consistently across HDSS study centers. 2. Develop/adapt methods to produce comparable, valid cause of death assessments from verbal autopsies. 3. Develop methods to minimize loss to follow-up for those who migrate from the study site over the long or short term.

Public Health Relevance

All subprojects of this program require accurate, comparable measures of all-cause and cause-specific mortality. The Mortality Core will work with the three HDSS sites to adapt and extend existing methods and procedures to produce these mortality indicators, and will monitor the program study cohorts and develop procedures to minimize loss to follow-up. Ultimately, the Mortality Core will contribute to the field by creating standardized methods for measuring all-cause and cause-specific mortality in resource-poor settings, characterize migration in and out of the study areas, and contribute to new verbal autopsy methods.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
1P01AG041710-01A1
Application #
8589050
Study Section
Special Emphasis Panel (ZAG1-ZIJ-1 (M1))
Project Start
2013-09-15
Project End
2016-07-31
Budget Start
2013-09-15
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$18,450
Indirect Cost
Name
Harvard University
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Harling, Guy; Morris, Katherine Ann; Manderson, Lenore et al. (2018) Age and Gender Differences in Social Network Composition and Social Support Among Older Rural South Africans: Findings From the HAALSI Study. J Gerontol B Psychol Sci Soc Sci :
Chetty, Terusha; Yapa, H Manisha N; Herbst, Carina et al. (2018) The MONARCH intervention to enhance the quality of antenatal and postnatal primary health services in rural South Africa: protocol for a stepped-wedge cluster-randomised controlled trial. BMC Health Serv Res 18:625
Gómez-Olivé, F Xavier; Montana, Livia; Wagner, Ryan G et al. (2018) Cohort Profile: Health and Ageing in Africa: a Longitudinal Study of an INDEPTH Community in South Africa (HAALSI). Int J Epidemiol :
Yapa, H Manisha; Bärnighausen, Till (2018) Implementation science in resource-poor countries and communities. Implement Sci 13:154
Harling, Guy; Gumede, Dumile; Shahmanesh, Maryam et al. (2018) Sources of social support and sexual behaviour advice for young adults in rural South Africa. BMJ Glob Health 3:e000955
Geldsetzer, Pascal; Fink, Günther; Vaikath, Maria et al. (2018) Sampling for Patient Exit Interviews: Assessment of Methods Using Mathematical Derivation and Computer Simulations. Health Serv Res 53:256-272
Gómez-Olivé, F Xavier; Rohr, Julia K; Roden, Laura C et al. (2018) Associations between sleep parameters, non-communicable diseases, HIV status and medications in older, rural South Africans. Sci Rep 8:17321
Kobayashi, Lindsay C; Berkman, Lisa F; Wagner, Ryan G et al. (2018) Education modifies the relationship between height and cognitive function in a cross-sectional population-based study of older adults in Rural South Africa. Eur J Epidemiol :
Payne, Collin F; Davies, Justine I; Gomez-Olive, F Xavier et al. (2018) Cross-sectional relationship between haemoglobin concentration and measures of physical and cognitive function in an older rural South African population. J Epidemiol Community Health 72:796-802
Hontelez, Jan A C; Bor, Jacob; Tanser, Frank C et al. (2018) HIV Treatment Substantially Decreases Hospitalization Rates: Evidence From Rural South Africa. Health Aff (Millwood) 37:997-1004

Showing the most recent 10 out of 36 publications