There is now a recognized need to include sophisticated informatics components to biomedical research. This is critical to the success of any multisite or coordinated effort and enables subsequent re-use of data and findings in unanticipated ways and greatly enhances the overall value of the project. Core C of the proposed P01 ?Vascular Contributions To Dementia And Genetic Risk Factors For Alzheimer?s Disease? will provide high quality computational, harmonization, and imaging resources for Projects 1, 2, and 3, Core B, and all P01 investigators, staff, and authorized scientists. The activities of Core C will support the scientific goals of the P01 as well as the broader national Alzheimer?s disease and dementia research community. Given the multimodality nature of data collected as a part of the P01, robust informatics, data management, and harmonization are critical. Core C will 1) provide an informatics data management framework for harmonized clinical and neuropsychological data for Projects 1 and 2, and harmonized imaging data for all P01 Projects. This centralized web-based data system will be used for registration and documentation of participants, including archival and tracking of raw and pre-processed data and open data dissemination; 2) ensure high quality control of all neuroimaging data across P01 Projects using a state-of-the-art workflow for the review and assessment of diffusion tensor imaging (DTI), functional MRI (fMRI), structural magnetic resonance imaging (MRI), dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL) MRI, and dynamic susceptibility contrast (DSC) MRI data; 3) deliver a harmonized analysis workflow for each imaging modality for each Project that can accommodate any computational environment via a user-friendly, uniform data analysis pipeline that is accessible to all investigators; and 4) coordinate biostatistical support for on analytic approach, data harmonization, and modeling of longitudinal datasets.
| Montagne, Axel; Nikolakopoulou, Angeliki M; Zhao, Zhen et al. (2018) Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med 24:326-337 |
| Sweeney, Melanie D; Zlokovic, Berislav V (2018) A lymphatic waste-disposal system implicated in Alzheimer's disease. Nature 560:172-174 |
| Li, Junning; Gahm, Jin Kyu; Shi, Yonggang et al. (2018) Topological false discovery rates for brain mapping based on signal height. Neuroimage 167:478-487 |
| Sweeney, Melanie D; Sagare, Abhay P; Zlokovic, Berislav V (2018) Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat Rev Neurol 14:133-150 |
| Amar, Arun Paul; Sagare, Abhay P; Zhao, Zhen et al. (2018) Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology 134:293-301 |
| Ho, Jean K; Nation, Daniel A; Alzheimer’s Disease Neuroimaging Initiative (2018) Neuropsychological Profiles and Trajectories in Preclinical Alzheimer's Disease. J Int Neuropsychol Soc 24:693-702 |
| Weissberger, Gali H; Nation, Daniel A; Nguyen, Caroline P et al. (2018) Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans. Neurosci Biobehav Rev 94:49-58 |
| Sinha, Ranjeet K; Wang, Yaoming; Zhao, Zhen et al. (2018) PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. Blood 131:1163-1171 |
| Nation, Daniel A; Tan, Alick; Dutt, Shubir et al. (2018) Circulating Progenitor Cells Correlate with Memory, Posterior Cortical Thickness, and Hippocampal Perfusion. J Alzheimers Dis 61:91-101 |
| Sweeney, Melanie D; Kisler, Kassandra; Montagne, Axel et al. (2018) The role of brain vasculature in neurodegenerative disorders. Nat Neurosci 21:1318-1331 |
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