Abstract

Six investigators will continue to study the cell and molecular biology of lymphoid cells. Cultured cell lines and somatic mutants derived from them will be used wherever possible. Immunologically important molecules from parental and mutant cells will be characterized structurally and functionally. Amongst the questions being addressed are: the origins and targets of NK cells, the biochemical basis of macrophage functions including anti-bacterial activity, the mechanism of unresponsiveness in leprosy, the nature and role of cross reactive idiotypes of anti-DNA antibodies in lupus, the molecular basis of MHC polymorphism and the structural basis of MHC function in cell-cell interactions and antigen presentation, and the molecular basis of the somatic generation of antibody diversity and gene rearrangement associated with B cell differentiation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI010702-14
Application #
3091412
Study Section
Transplantation and Immunology Committee (TIC)
Project Start
1977-06-01
Project End
1987-04-30
Budget Start
1985-05-01
Budget End
1986-04-30
Support Year
14
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Bard, J A; Birshtein, B K (1995) Rearrangement of a VH-associated LINE-1 element with the expressed IgH cluster in a murine myeloma cell line. J Immunol 154:201-8
Singh, M; Birshtein, B K (1993) NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation. Mol Cell Biol 13:3611-22
Paul, E; Diamond, B (1993) Characterization of two human anti-DNA antibodies bearing the pathogenic idiotype 8.12. Autoimmunity 16:13-21
Wettstein, P J; van Bleek, G M; Nathenson, S G (1993) Differential binding of a minor histocompatibility antigen peptide to H-2 class I molecules correlates with immune responsiveness. J Immunol 150:2753-60
Ishikawa, S; Kowal, C; Diamond, B (1993) An E alpha E beta heterodimer dramatically alters selection of functional T-cell subsets in A.CA transgenic mice. Immunogenetics 38:296-9
Giannini, S L; Singh, M; Calvo, C F et al. (1993) DNA regions flanking the mouse Ig 3' alpha enhancer are differentially methylated and DNAase I hypersensitive during B cell differentiation. J Immunol 150:1772-80
Mukherjee, J; Casadevall, A; Scharff, M D (1993) Mu switch region deletion is associated with both T cell independent and T cell dependent responses. Mol Immunol 30:1049-55
Kesari, K V; Van Bleek, G; Nathenson, S G et al. (1993) A single amino acid substitution in the H-2Kb molecule generates a defined allogeneic epitope. Mol Immunol 30:1671-7
Mukherjee, J; Casadevall, A; Scharff, M D (1993) Molecular characterization of the humoral responses to Cryptococcus neoformans infection and glucuronoxylomannan-tetanus toxoid conjugate immunization. J Exp Med 177:1105-16
Cross, A H; Ishikawa, S; Raine, C S et al. (1992) Autoimmune demyelination in transgenic E alpha d-positive A.CA mice. Comparison with E-negative A.CA mice. Lab Invest 66:598-607

Showing the most recent 10 out of 95 publications