Diseases caused by the Leishmania-Trypanosoma complex are of major importance in the Wester Hemisphere. The diseases exhibit marked variation in clinical manifestations yet, taxonomically, biochemically and immunologically, they maintain many similarities which may provide clues to pathogenesis. Control of these diseases will result from careful evaluation of pathogenic mechanisms, antimicrobial therapy, disease patterns, and methods of accurate diagnosis. This program project brings together basic science and clinical investigators from Cornell University Medical College and The Rockefeller University and respected Brazilian investigators from the University of Bahia and the University of Brasilia. The central focus of this collaborative effort is the integration of basic and applied clinical research. The major research areas include: 1) basic parasitology, immunobiology and pharmacology of Chagas' disease and leishmaniasis; 2) clinical disease patterns, epidemiology and genetics these disease; and 3) application of immunologic techniques for understanding pathogenesis and for reliable diagnosis. Central to this grant is the attempt to coordinate the activities of investigators from different disciplines to allow exchange of limited resources, to bring these investigators in contact with young researchers abroad, and to advance our understanding of important human diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI016282-10
Application #
3091480
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Project Start
1979-09-30
Project End
1989-08-31
Budget Start
1988-09-01
Budget End
1989-08-31
Support Year
10
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065