The overall purpose of the development of the Johns Hopkins STD Research Unit is to create an identifiable focal point for institutional research activities directed toward the STDs. As a result, the many investigators involved in relevant research will become increasingly aware of others with similar and complementary interests. This inevitably will create more opportunities for collaborative, multidisciplinary research and promote a greater interchange of ideas. It is further believed that both new and established investigators with appropriate skills will be recruited to the field. As a corollary, education of individuals in the laboratory, clinical, epidemiologic and control aspects of the STDs will be expanded and strengthened. Another consequence will be the strengthening of the University's research resources. This will come about through an improvement in the organization of the clinical and laboratory facilities of the Johns Hopkins Hospital (JHH) and possibly the establishment of an STD clinic for adults and males. There will also be closer relationship with the Baltimore City Health Department (BCHD) STD program and clinics and the laboratories of the Maryland State Department of Health and Mental Hygiene (MPHL) with greater use of their facilities and services. The core unit will be involved in not only the general administration and coordination of the program project but in the development of additional, human, physical and fiscal resources to strengthen the several projects embraced in the application and to broaden the research activities in the institutions involved. The projects address problems in the laboratory, clinical and epidemiological aspects of the STDs. Laboratory projects are designed to provide a better understanding of the agents, immune responses and/or pathogenesis of the following important STDs: syphilis (3), gonorrhea (6), cytomegalovirus infection (2), genital herpes (1), and venereal warts (7). Project 8 is a clinical study which involves collaboration with each of the above laboratories, as well as the BCHD STD clinics and the MPHL. Project 4 is a combined clinical, laboratory and epidemiologic study using the JHH and the BCHD STD clinics. Project 5, an epidemiologic investigation, will utilize patients selected from the BCHD STD clinics and the JHH. The investigators have and will continue to meet as a g (Text Truncated - Exceeds Capacity)

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
Project #
Application #
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Schools of Public Health
United States
Zip Code
Thomas, D L; Zenilman, J M; Alter, H J et al. (1995) Sexual transmission of hepatitis C virus among patients attending sexually transmitted diseases clinics in Baltimore--an analysis of 309 sex partnerships. J Infect Dis 171:768-75
Thomas, D L; Rompalo, A M; Zenilman, J et al. (1994) Association of hepatitis C virus infection with false-positive tests for syphilis. J Infect Dis 170:1579-81
West, S; Munoz, B; Bobo, L et al. (1993) Nonocular Chlamydia infection and risk of ocular reinfection after mass treatment in a trachoma hyperendemic area. Invest Ophthalmol Vis Sci 34:3194-8
Kessis, T D; Slebos, R J; Han, S M et al. (1993) p53 gene mutations and MDM2 amplification are uncommon in primary carcinomas of the uterine cervix. Am J Pathol 143:1398-405
Kessis, T D; Slebos, R J; Nelson, W G et al. (1993) Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. Proc Natl Acad Sci U S A 90:3988-92
Guerrero, E; Daniel, R W; Bosch, F X et al. (1992) Comparison of ViraPap, Southern hybridization, and polymerase chain reaction methods for human papillomavirus identification in an epidemiological investigation of cervical cancer. J Clin Microbiol 30:2951-9
Hermonat, P L; Daniel, R W; Shah, K V (1992) The spermicide nonoxynol-9 does not inactivate papillomavirus. Sex Transm Dis 19:203-5
Coutlee, F; Bobo, L; Abbass, H et al. (1992) Detection of HPV-16 in cell lines and cervical lavage specimens by a polymerase chain reaction-enzyme immunoassay assay. J Med Virol 37:22-9
Upchurch, D M; Ray, P; Reichart, C et al. (1992) Prevalence and patterns of condom use among patients attending a sexually transmitted disease clinic. Sex Transm Dis 19:175-80
Muller, M; Viscidi, R P; Sun, Y et al. (1992) Antibodies to HPV-16 E6 and E7 proteins as markers for HPV-16-associated invasive cervical cancer. Virology 187:508-14

Showing the most recent 10 out of 58 publications