Abstract

This program Project brings together five investigators at Stanford University who are studying the role of MHC Class II molecules, CD4, CD8, and T cell receptor molecules, B cell receptor molecules, cytokines and developmentally expressed gene products. Its focus is on the developments differentiation, structure, function, and interaction of T cells, B cells, and macrophages in the generation of a normal immune responses as well as in several autoimmune diseases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
2P01AI019512-13A1
Application #
2060948
Study Section
Allergy & Clinical Immunology-1 (AITC)
Project Start
1983-05-01
Project End
1999-08-31
Budget Start
1995-09-30
Budget End
1996-08-31
Support Year
13
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Pogue, S L; Goodnow, C C (2000) Gene dose-dependent maturation and receptor editing of B cells expressing immunoglobulin (Ig)G1 or IgM/IgG1 tail antigen receptors. J Exp Med 191:1031-44
Frank, G D; Parnes, J R (1998) The level of CD4 surface protein influences T cell selection in the thymus. J Immunol 160:634-42
Zhang, X L; Seong, R; Piracha, R et al. (1998) Distinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8 alpha at double- and single-positive stages of thymic development. J Immunol 161:2254-66
Messika, E J; Lu, P S; Sung, Y J et al. (1998) Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development. J Exp Med 188:515-25
Townsend, S E; Goodnow, C C (1998) Abortive proliferation of rare T cells induced by direct or indirect antigen presentation by rare B cells in vivo. J Exp Med 187:1611-21
Akkaraju, S; Canaan, K; Goodnow, C C (1997) Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells. J Exp Med 186:2005-12
Akkaraju, S; Ho, W Y; Leong, D et al. (1997) A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity 7:255-71
Reich, Z; Altman, J D; Boniface, J J et al. (1997) Stability of empty and peptide-loaded class II major histocompatibility complex molecules at neutral and endosomal pH: comparison to class I proteins. Proc Natl Acad Sci U S A 94:2495-500
Conboy, I M; DeKruyff, R H; Tate, K M et al. (1997) Novel genetic regulation of T helper 1 (Th1)/Th2 cytokine production and encephalitogenicity in inbred mouse strains. J Exp Med 185:439-51
Fournier, S; Rathmell, J C; Goodnow, C C et al. (1997) T cell-mediated elimination of B7.2 transgenic B cells. Immunity 6:327-39

Showing the most recent 10 out of 77 publications