Abstract

This core laboratory (Core A) will be responsible for molecular detection of human papillomavirus DNA in the clinical specimens from Projects 1 (Perinatal and Childhood Transmission of HPV Infections) and 2 (Acquisition and Natural History of Genital HPV Infections). The procedures that will be used to determine HPV presence and type in human tissues are the polymerase chain reaction and Southern transfer hybridizations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI029363-05
Application #
3747078
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109

  Publications

Watts, D H; Koutsky, L A; Holmes, K K et al. (1998) Low risk of perinatal transmission of human papillomavirus: results from a prospective cohort study. Am J Obstet Gynecol 178:365-73
Carter, J J; Koutsky, L A; Wipf, G C et al. (1996) The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women. J Infect Dis 174:927-36
Hagensee, M E; Carter, J J; Wipf, G C et al. (1995) Immunization of mice with HPV vaccinia virus recombinants generates serum IgG, IgM, and mucosal IgA antibodies. Virology 206:174-82
Ostrow, R S; Coughlin, S M; McGlennen, R C et al. (1995) Serological and molecular evidence of rhesus papillomavirus type 1 infections in tissues from geographically distinct institutions. J Gen Virol 76 ( Pt 2):293-9
Baken, L A; Koutsky, L A; Kuypers, J et al. (1995) Genital human papillomavirus infection among male and female sex partners: prevalence and type-specific concordance. J Infect Dis 171:429-32
Xi, L F; Demers, G W; Koutsky, L A et al. (1995) Analysis of human papillomavirus type 16 variants indicates establishment of persistent infection. J Infect Dis 172:747-55
Carter, J J; Hagensee, M B; Lee, S K et al. (1994) Use of HPV 1 capsids produced by recombinant vaccinia viruses in an ELISA to detect serum antibodies in people with foot warts. Virology 199:284-91
McDougall, J K (1994) Immortalization and transformation of human cells by human papillomavirus. Curr Top Microbiol Immunol 186:101-19
Xi, L F; Demers, W; Kiviat, N B et al. (1993) Sequence variation in the noncoding region of human papillomavirus type 16 detected by single-strand conformation polymorphism analysis. J Infect Dis 168:610-7
Merrick, D T; Gown, A M; Halbert, C L et al. (1993) Human papillomavirus-immortalized keratinocytes are resistant to the effects of retinoic acid on terminal differentiation. Cell Growth Differ 4:831-40

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