Abstract

This program focuses on host-parasite relationships in Lyme disease. How does the organism interact with the host to produce the diverse clinical pathologic manifestations of the disease? How does the host's immune system respond to borrelial antigens in protective and pathogenotic ways?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI030548-03
Application #
3092087
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Project Start
1991-09-30
Project End
1995-08-31
Budget Start
1993-09-01
Budget End
1994-08-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Magnarelli, L; Fikrig, E (2005) Detection of antibodies to Borrelia burgdorferi in naturally infected horses in the USA by enzyme-linked immunosorbent assay using whole-cell and recombinant antigens. Res Vet Sci 79:99-103
Moro, Manuel H; Zegarra-Moro, Ofelia L; Bjornsson, Johannes et al. (2002) Increased arthritis severity in mice coinfected with Borrelia burgdorferi and Babesia microti. J Infect Dis 186:428-31
Magnarelli, Louis A; Lawrenz, Matthew; Norris, Steven J et al. (2002) Comparative reactivity of human sera to recombinant VlsE and other Borrelia burgdorferi antigens in class-specific enzyme-linked immunosorbent assays for Lyme borreliosis. J Med Microbiol 51:649-55
Magnarelli, L A; Levy, S A; Ijdo, J W et al. (2001) Reactivity of dog sera to whole-cell or recombinant antigens of Borrelia burgdorferi by ELISA and immunoblot analysis. J Med Microbiol 50:889-95
Moro, M H; Bjornsson, J; Marietta, E V et al. (2001) Gestational attenuation of Lyme arthritis is mediated by progesterone and IL-4. J Immunol 166:7404-9
Das, S; Marcantonio, N; Deponte, K et al. (2000) SALP16, a gene induced in Ixodes scapularis salivary glands during tick feeding. Am J Trop Med Hyg 62:99-105
Malawista, S E; Montgomery, R R; Wang, X M et al. (2000) Geographic clustering of an outer surface protein A mutant of Borrelia burgdorferi. Possible implications of multiple variants for Lyme disease persistence. Rheumatology (Oxford) 39:537-41
Magnarelli, L A; Ijdo, J W; Padula, S J et al. (2000) Serologic diagnosis of Lyme borreliosis by using enzyme-linked immunosorbent assays with recombinant antigens. J Clin Microbiol 38:1735-9
Malawista, S E; de Boisfleury Chevance, A; Boxer, L A (2000) Random locomotion and chemotaxis of human blood polymorphonuclear leukocytes from a patient with leukocyte adhesion deficiency-1: normal displacement in close quarters via chimneying. Cell Motil Cytoskeleton 46:183-9
Eynon, E E; Livak, F; Kuida, K et al. (1999) Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development. J Immunol 162:1448-59

Showing the most recent 10 out of 120 publications