Abstract

The Pathology/Microbiology Core provides a centralized service for all projects so that animal and bacterial elements of program experiments are standardized and high quality. The core generates quality-controlled medium for growth of B. burgdorferi; B. burgdorferi isolates for use in laboratory animals; culture of B. burgdorferi from animal tissues; technical services for standardized inoculation, immunization and tissue collection; coordination of animal experiments utilizing core services; and professional pathology services for evaluation of tissues from experimental animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI030548-06
Application #
5205432
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Magnarelli, L; Fikrig, E (2005) Detection of antibodies to Borrelia burgdorferi in naturally infected horses in the USA by enzyme-linked immunosorbent assay using whole-cell and recombinant antigens. Res Vet Sci 79:99-103
Moro, Manuel H; Zegarra-Moro, Ofelia L; Bjornsson, Johannes et al. (2002) Increased arthritis severity in mice coinfected with Borrelia burgdorferi and Babesia microti. J Infect Dis 186:428-31
Magnarelli, Louis A; Lawrenz, Matthew; Norris, Steven J et al. (2002) Comparative reactivity of human sera to recombinant VlsE and other Borrelia burgdorferi antigens in class-specific enzyme-linked immunosorbent assays for Lyme borreliosis. J Med Microbiol 51:649-55
Magnarelli, L A; Levy, S A; Ijdo, J W et al. (2001) Reactivity of dog sera to whole-cell or recombinant antigens of Borrelia burgdorferi by ELISA and immunoblot analysis. J Med Microbiol 50:889-95
Moro, M H; Bjornsson, J; Marietta, E V et al. (2001) Gestational attenuation of Lyme arthritis is mediated by progesterone and IL-4. J Immunol 166:7404-9
Das, S; Marcantonio, N; Deponte, K et al. (2000) SALP16, a gene induced in Ixodes scapularis salivary glands during tick feeding. Am J Trop Med Hyg 62:99-105
Malawista, S E; Montgomery, R R; Wang, X M et al. (2000) Geographic clustering of an outer surface protein A mutant of Borrelia burgdorferi. Possible implications of multiple variants for Lyme disease persistence. Rheumatology (Oxford) 39:537-41
Magnarelli, L A; Ijdo, J W; Padula, S J et al. (2000) Serologic diagnosis of Lyme borreliosis by using enzyme-linked immunosorbent assays with recombinant antigens. J Clin Microbiol 38:1735-9
Malawista, S E; de Boisfleury Chevance, A; Boxer, L A (2000) Random locomotion and chemotaxis of human blood polymorphonuclear leukocytes from a patient with leukocyte adhesion deficiency-1: normal displacement in close quarters via chimneying. Cell Motil Cytoskeleton 46:183-9
Eynon, E E; Livak, F; Kuida, K et al. (1999) Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development. J Immunol 162:1448-59

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