Abstract

The Clinical Core, based at the Seattle-King County Department of Public Health's STD Clinic at Harborview Medical Center, will recruit subjects as sources of clinical material and specimens for the studies of molecular immunology in syphilis and genital herpes. A designated mid-level clinician will enroll suitable subjects, collect the necessary clinical specimens, and arrange for prospective follow-up.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
3P01AI034616-05S1
Application #
6099678
Study Section
Project Start
1998-09-01
Project End
2000-02-29
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Lukehart, Sheila A (2008) Scientific monogamy: thirty years dancing with the same bug: 2007 Thomas Parran Award Lecture. Sex Transm Dis 35:2-7
Godornes, Charmie; Leader, Brandon Troy; Molini, Barbara J et al. (2007) Quantitation of rabbit cytokine mRNA by real-time RT-PCR. Cytokine 38:1-7
Leader, Brandon T; Godornes, Charmie; VanVoorhis, Wesley C et al. (2007) CD4+ lymphocytes and gamma interferon predominate in local immune responses in early experimental syphilis. Infect Immun 75:3021-6
Giacani, Lorenzo; Molini, Barbara; Godornes, Charmie et al. (2007) Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis. Infect Immun 75:104-12
LaFond, Rebecca E; Molini, Barbara J; Van Voorhis, Wesley C et al. (2006) Antigenic variation of TprK V regions abrogates specific antibody binding in syphilis. Infect Immun 74:6244-51
Centurion-Lara, Arturo; Molini, Barbara J; Godornes, Charmie et al. (2006) Molecular differentiation of Treponema pallidum subspecies. J Clin Microbiol 44:3377-80
Mitchell, Samuel J; Engelman, Joseph; Kent, Charlotte K et al. (2006) Azithromycin-resistant syphilis infection: San Francisco, California, 2000-2004. Clin Infect Dis 42:337-45
LaFond, Rebecca E; Centurion-Lara, Arturo; Godornes, Charmie et al. (2006) TprK sequence diversity accumulates during infection of rabbits with Treponema pallidum subsp. pallidum Nichols strain. Infect Immun 74:1896-906
Gray, R R; Mulligan, C J; Molini, B J et al. (2006) Molecular evolution of the tprC, D, I, K, G, and J genes in the pathogenic genus Treponema. Mol Biol Evol 23:2220-33
Sun, Eileen S; Molini, Barbara J; Barrett, Lynn K et al. (2004) Subfamily I Treponema pallidum repeat protein family: sequence variation and immunity. Microbes Infect 6:725-37

Showing the most recent 10 out of 49 publications