Abstract

Class I molecules are able to present antigens from opportunistic microorganisms to CD8 T cells. In this grant we will dissect the role of class IB antigens in this process. This includes determining how IB molecules present ligands recognized by alpha-beta as well as gamma-delta T cells, identifying the peptides that IB molecules present, and defining peptide motifs for several class IB alleles. We will extend our knowledge of class IB genes/antigens by characterizing newly identified genes in the Q, T, and M regions of the murine MHC. The role of Tap molecules in antigen presentation will be investigated by assessing what effect polymorphisms in human Tap genes have on their function. Together, this grant will integrate the structure/function of class IB molecules in the presentation of ligands derived from infectious organisms responsible for disease in immunocompromised individuals as well as determine how Tap molecules function in antigen presentation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
1P01AI037818-01
Application #
2074692
Study Section
Allergy & Clinical Immunology-1 (AITC)
Project Start
1995-09-15
Project End
1999-08-31
Budget Start
1995-09-15
Budget End
1996-08-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Lambracht-Washington, Doris; Moore, Yuki F; Wonigeit, Kurt et al. (2008) Structure and expression of MHC class Ib genes of the central M region in rat and mouse: M4, M5, and M6. Immunogenetics 60:131-45
Chen, Ming; Tabaczewski, Piotr; Truscott, Steven M et al. (2005) Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway. J Immunol 175:1047-55
Gunturi, Anasuya; Berg, Rance E; Crossley, Emily et al. (2005) The role of TCR stimulation and TGF-beta in controlling the expression of CD94/NKG2A receptors on CD8 T cells. Eur J Immunol 35:766-75
Gimenez-Barcons, Mireia; Wang, Chunfu; Chen, Ming et al. (2005) The oncogenic potential of hepatitis C virus NS5A sequence variants is associated with PKR regulation. J Interferon Cytokine Res 25:152-64
Moore, Yuki F; Lambracht-Washington, Doris; Tabaczewski, Piotr et al. (2004) Murine MHC class Ib gene, H2-M2, encodes a conserved surface-expressed glycoprotein. Immunogenetics 56:1-11
Lambracht-Washington, Doris; Fischer Lindahl, Kirsten (2004) Active MHC class Ib genes in rat are pseudogenes in the mouse. Immunogenetics 56:118-21
Hermel, Evan; Hart, Andrew J; Gunduz, Irfan et al. (2004) Polymorphism and conservation of the genes encoding Qa1 molecules. Immunogenetics 56:639-49
Kumanovics, Attila; Fischer Lindahl, Kirsten (2004) Good copy, bad copy: choosing animal models for HLA-linked diseases. Curr Opin Genet Dev 14:258-63
Gunturi, Anasuya; Berg, Rance E; Forman, James (2004) The role of CD94/NKG2 in innate and adaptive immunity. Immunol Res 30:29-34
Kurepa, Zoran; Su, Jie; Forman, James (2003) Memory phenotype of CD8+ T cells in MHC class Ia-deficient mice. J Immunol 170:5414-20

Showing the most recent 10 out of 45 publications