The mission of the Characterization and Formulation Core is to provide support to Projects 1, 2 and 3 by: 1) developing simple formulations; 2) performing sperm function inhibition tests; 3) evaluating their safety/toxicity potential; and 4) developing clinically advantageous formulations. Agents will be prioritized based on their in vitro antimicrobial properties (Projects 1 and 2). Simple formulations whose bases are inactive will be developed for high priority compounds and tested in animal models (Project 3). Sperm function inhibition tests will characterize the compounds as potential noncontraceptive and contraceptive antimicrobials. Based on these results as well as other considerations, the compounds will be reprioritized. Initial safety/toxicity studies will be performed with the most desirable compounds. Those which appear safe will be considered candidates for pre-IND development and clinical trial. Clinically advantageous formulations will be developed which should further increase and maximize the antimicrobial properties of the compounds. The outcome of this work will be the availability of novel, tentatively safe and potentially clinically useful active ingredients/formulations for further preclinical development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
7P01AI037940-07
Application #
6434077
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2000-09-30
Project End
2001-08-31
Budget Start
Budget End
Support Year
7
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
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Milligan, Gregg N; Chu, Chin-Fun; Young, Christal G et al. (2004) Effect of candidate vaginally-applied microbicide compounds on recognition of antigen by CD4+ and CD8+ T lymphocytes. Biol Reprod 71:1638-45

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