This program project has assembled molecular biologist, immunologist, population geneticist andclinical scientist to investigate the mechanism of co-stimulatory responses in patients with MS and type 1diabetes, and examine the hypothesis that a genetic predisposition for alterations in co-stimulatory signalleads to heightened inflammatory responses that in part underlies the pathophysiology of autoimmunediseases. To accomplish these goals, an administrative core is requested to ensure that financial activitiesamong project participants are in compliance with the appropriate NIH policies and guidelines throughout theproject period and to facilitate the report of our findings on an annual basis to the NIH. Additionally, animportant function of the administrative core will be the arrangement of monthly conference calls among thePPG participants and arranging the bi-annual meetings of the advisory board. Thus funding theadministrative core is important to accomplish the goals of the PPG.
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