Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
3P01AI039676-02S1
Application #
2561535
Study Section
Special Emphasis Panel (ZAI1-PSS-I (42))
Project Start
1996-06-01
Project End
2000-05-31
Budget Start
1997-06-01
Budget End
1998-05-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Washington University
Department
Pathology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Ranganath, S; Murphy, K M (2001) Structure and specificity of GATA proteins in Th2 development. Mol Cell Biol 21:2716-25
Farrar, J D; Smith, J D; Murphy, T L et al. (2000) Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2. J Biol Chem 275:2693-7
Murphy, T L; Geissal, E D; Farrar, J D et al. (2000) Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation. Mol Cell Biol 20:7121-31
Carter, L L; Murphy, K M (1999) Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells. J Exp Med 189:1355-60
Pakala, S V; Chivetta, M; Kelly, C B et al. (1999) In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha. J Exp Med 189:1053-62
Yang, J; Murphy, T L; Ouyang, W et al. (1999) Induction of interferon-gamma production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation. Eur J Immunol 29:548-55
Guler, M L; Gorham, J D; Dietrich, W F et al. (1999) Tpm1, a locus controlling IL-12 responsiveness, acts by a cell-autonomous mechanism. J Immunol 162:1339-47
Gorham, J D; Guler, M L; Fenoglio, D et al. (1998) Low dose TGF-beta attenuates IL-12 responsiveness in murine Th cells. J Immunol 161:1664-70
Ouyang, W; Ranganath, S H; Weindel, K et al. (1998) Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9:745-55
Kurrer, M O; Pakala, S V; Hanson, H L et al. (1997) Beta cell apoptosis in T cell-mediated autoimmune diabetes. Proc Natl Acad Sci U S A 94:213-8

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