Abstract

The Animal Core will provide the basic support for the maintenance of the strains necessary for this project which are not commercially available. It will not support the production of the mice used in experiments, but rather the basal level of breeding necessary for the maintenance of unique mouse strains. The applicants will maintain the diabetic mouse, NOD, as well as four GKO mice bred onto the NOD background. In addition, the investigators will maintain the class II MHC, DM and CIITA GKO mice. Finally, the applicants will maintain LCMB TCR transgenics as well as two single chain class I transgenic, LCMV gp RIP and ubiquitous expression transgenics at the core. The Animal Core is expected to be economical, eliminating the need for each investigator to maintain their own breeding colonies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI041580-03
Application #
6201375
Study Section
Project Start
1999-08-01
Project End
2000-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

van Deventer, Hendrik W; Serody, Jonathon S; McKinnon, Karen P et al. (2002) Transfection of macrophage inflammatory protein 1 alpha into B16 F10 melanoma cells inhibits growth of pulmonary metastases but not subcutaneous tumors. J Immunol 169:1634-9
June Brickey, W; Felix, Nathan J; Griffiths, Robert et al. (2002) Prolonged survival of class II transactivator-deficient cardiac allografts. Transplantation 74:1341-8
Felix, Nathan J; de Serres, Suzan; Meyer, Anthony A et al. (2002) Comparison of Abeta(b-/-), H2-DM(-), and CIITA(-/-) in second-set skin allograft rejection. J Surg Res 102:185-92
Tisch, R; Wang, B; Weaver, D J et al. (2001) Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination. J Immunol 166:2122-32
Taxman, D J; Ting, J P (2001) Identification of novel Mycoplasma hyorhinis gene fragments by differential display analysis of co-cultures. J Microbiol Methods 44:217-23
Weaver Jr, D J; Liu, B; Tisch, R (2001) Plasmid DNAs encoding insulin and glutamic acid decarboxylase 65 have distinct effects on the progression of autoimmune diabetes in nonobese diabetic mice. J Immunol 167:586-92
Maile, R; Wang, B; Schooler, W et al. (2001) Antigen-specific modulation of an immune response by in vivo administration of soluble MHC class I tetramers. J Immunol 167:3708-14
Taxman, D J; Cressman, D E; Ting, J P (2000) Identification of class II transcriptional activator-induced genes by representational difference analysis: discoordinate regulation of the DN alpha/DO beta heterodimer. J Immunol 165:1410-6
Wang, B; Maile, R; Greenwood, R et al. (2000) Naive CD8+ T cells do not require costimulation for proliferation and differentiation into cytotoxic effector cells. J Immunol 164:1216-22
White 2nd, G C; Greenwood, R; Escobar, M et al. (2000) Hemophilia factor VIII therapy. Immunological tolerance. A clinical perspective. Haematologica 85:113-6

Showing the most recent 10 out of 16 publications