This program project application will serve to coordinate a multi-center approach to the design, synthesis, characterization, and testing of molecules that inhibit HIV-1 replication through inhibition of HIV-1 co- receptor activity. An outstanding international team of investigators has been selected for their potentially useful molecules through in vitro and in vivo testing. Project I will design and synthesize modified chemokine molecules that have promise as inhibitors of HIV co-receptor activity. Project II will test promising molecules for their activity against a variety of HIV clinical isolates and will characterize the emergence of resistance to these agents. Project III will examine the activity of promising compounds in the hu- PBL-SCID mouse. These studies will test the potential utility of targeting HIV co- receptors as a treatment strategy in HIV disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI043645-03
Application #
6171011
Study Section
Special Emphasis Panel (ZAI1-ACS-A (M2))
Program Officer
Bridges, Sandra H
Project Start
1998-09-30
Project End
2002-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
3
Fiscal Year
2000
Total Cost
$849,816
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106