Abstract

Public Health Relevance

There is an urgent need for an effective vaccine to combat the worldwide AIDS epidemic. These research studies will lead to important information about a novel AIDS vaccine vector based on herpes simplex virus recombinants expressing SIV and HIV proteins. This novel vaccine approach could have a large impact on this major medical problem.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
3P01AI046006-10S1
Application #
8135142
Study Section
Special Emphasis Panel (ZAI1-EC-A (M2))
Project Start
2010-08-15
Project End
2011-03-31
Budget Start
2010-08-15
Budget End
2011-03-31
Support Year
10
Fiscal Year
2010
Total Cost
$164,162
Indirect Cost

  Institution

Name
Harvard University
Department
Type
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Meythaler, Mareike; Wang, Zichun; Martinot, Amanda et al. (2011) Early induction of polyfunctional simian immunodeficiency virus (SIV)-specific T lymphocytes and rapid disappearance of SIV from lymph nodes of sooty mangabeys during primary infection. J Immunol 186:5151-61
Reszka, Natalia; Zhou, Changhong; Song, Byeongwoon et al. (2010) Simian TRIM5alpha proteins reduce replication of herpes simplex virus. Virology 398:243-50
Meythaler, Mareike; Martinot, Amanda; Wang, Zichun et al. (2009) Differential CD4+ T-lymphocyte apoptosis and bystander T-cell activation in rhesus macaques and sooty mangabeys during acute simian immunodeficiency virus infection. J Virol 83:572-83
Liu, Xueqiao; Broberg, Eeva; Watanabe, Daisuke et al. (2009) Genetic engineering of a modified herpes simplex virus 1 vaccine vector. Vaccine 27:2760-7
Cliffe, Anna R; Garber, David A; Knipe, David M (2009) Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters. J Virol 83:8182-90
Brockman, Mark A; Knipe, David M (2008) Herpes simplex virus as a tool to define the role of complement in the immune response to peripheral infection. Vaccine 26 Suppl 8:I94-9
Cliffe, Anna R; Knipe, David M (2008) Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection. J Virol 82:12030-8
Meythaler, Mareike; Pryputniewicz, Sarah; Kaur, Amitinder (2008) Kinetics of T lymphocyte apoptosis and the cellular immune response in SIVmac239-infected rhesus macaques. J Med Primatol 37 Suppl 2:33-45
Watanabe, Daisuke; Brockman, Mark A; Ndung'u, Thumbi et al. (2007) Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector. Virology 357:186-98
Kaur, Amitinder; Sanford, Hannah B; Garry, Deirdre et al. (2007) Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus. Virology 357:199-214

Showing the most recent 10 out of 13 publications