The Non-human Primate Immunology Core will provide the laboratory support necessary to evaluate the effectiveness of the vaccine candidates being tested in Projects 1-3. The support will include cellular and humoral immunology assays capable of testing the ability of the immunized and or challenged macaques and chimpanzees to respond to the live viral vaccines. We will work closely with the PI's of each project to monitor the immune responses and provide feedback on any alterations that might enhance the immunogenicity of the respective vaccines.
Our specific aims are: 1) To utilize the latest and best assays of cellular immune function to evaluate macaque and chimpanzee cellular immune responses to the live viral vaccines created by projects 1-3, 2) To characterize the antibody responses in these animals to the vaccine viruses as well as the inserted HIV or SIV antigens, and 3) To prepare and maintain autologous B cell lines and other immunologic reagents necessary for the above assays.
|Naim, Hussein Y (2015) Measles virus. Hum Vaccin Immunother 11:21-6|
|Naim, Hussein Y (2013) Applications and challenges of multivalent recombinant vaccines. Hum Vaccin Immunother 9:457-61|
|Knuchel, Marlyse C; Marty, René R; Morin, Teldja Neige Azzouz et al. (2013) Relevance of a pre-existing measles immunity prior immunization with a recombinant measles virus vector. Hum Vaccin Immunother 9:599-606|
|Zuniga, Amando; Liniger, Mathias; Morin, Teldja Neige Azzouz et al. (2013) Sequence and immunogenicity of a clinically approved novel measles virus vaccine vector. Hum Vaccin Immunother 9:607-13|
|Liniger, Matthias; Zuniga, Armando; Morin, Teldja Neige Azzouz et al. (2009) Recombinant measles viruses expressing single or multiple antigens of human immunodeficiency virus (HIV-1) induce cellular and humoral immune responses. Vaccine 27:3299-305|
|Guerbois, Mathilde; Moris, Arnaud; Combredet, Chantal et al. (2009) Live attenuated measles vaccine expressing HIV-1 Gag virus like particles covered with gp160DeltaV1V2 is strongly immunogenic. Virology 388:191-203|
|Cantarella, Giuseppina; Liniger, Matthias; Zuniga, Armando et al. (2009) Recombinant measles virus-HPV vaccine candidates for prevention of cervical carcinoma. Vaccine 27:3385-90|
|Liniger, Matthias; Zuniga, Armando; Tamin, Azaibi et al. (2008) Induction of neutralising antibodies and cellular immune responses against SARS coronavirus by recombinant measles viruses. Vaccine 26:2164-74|
|Zuniga, Armando; Wang, Zili; Liniger, Matthias et al. (2007) Attenuated measles virus as a vaccine vector. Vaccine 25:2974-83|
|Liniger, Matthias; Zuniga, Armando; Naim, Hussein Y (2007) Use of viral vectors for the development of vaccines. Expert Rev Vaccines 6:255-66|
Showing the most recent 10 out of 20 publications