Atopic asthma and other allergic diseases are caused by a pathologic response of individuals to environmental antigens. To cure these diseases will require an understanding of the mechanisms that are required to initiate these immune responses and the mechanisms required to propagate them. One of the major paradigms that recent research in this field has generated is that both the initiation and propagation of allergic immune responses requires the interaction of different inflammatory cells. In addition, this interaction requires the exchange of information between these cells. Central to the exchange of information between cells involved in an allergic immune response is the use of signaling pathways to transmit these signals to the nucleus of the cells. This realization has begun to drive therapeutic research in the direction of altering these signaling pathways in order to modify the resultant allergic immune response. This Research Center seeks to understand the role of signaling pathways in allergic and asthmatic immune responses. In Project 1, Dr. Schindler proposes to study the role of STAT signaling in the development and function of Dendritic Cells (DC). In Project 2, Dr. Pernis will study the regulation of CD23 in normal and allergic humans. In Project 3, Dr. Clynes will study the role of Fc receptors in the initiation and propagation of allergic and asthmatic immune responses. In Project 4, Dr. Rothman will study how Pim kinases alter IL-4 signaling and how this alters allergic immune responses. In Project 5, Dr. Miller will study the immune response of the unborn child. The knowledge gained by this Center will improve our understanding of the signaling pathways required for an allergic immune response. A Scientific Core and an Administrative Core will support these projects. The Scientific Core will provide technical expertise and assistance in murine models of asthma and allergic immune responses. The Administrative Core will assist in organizing the Center?s activities.
| Melillo, Jessica A; Song, Li; Bhagat, Govind et al. (2010) Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function. J Immunol 184:2638-45 |
| Schindler, Christian; Plumlee, Courtney (2008) Inteferons pen the JAK-STAT pathway. Semin Cell Dev Biol 19:311-8 |
| Rastogi, Deepa; Wang, Chaodong; Mao, Xia et al. (2007) Antigen-specific immune responses to influenza vaccine in utero. J Clin Invest 117:1637-46 |
| Harbers, Stephanie O; Crocker, Andrea; Catalano, Geoffrey et al. (2007) Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance. J Clin Invest 117:1361-9 |
| Desai, Dharmesh D; Harbers, Stephanie O; Flores, Marcella et al. (2007) Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses. J Immunol 178:6217-26 |
| Rastogi, D; Wang, C; Lendor, C et al. (2006) T-helper type 2 polarization among asthmatics during and following pregnancy. Clin Exp Allergy 36:892-8 |
| Kashiwada, Masaki; Cattoretti, Giorgio; McKeag, Lisa et al. (2006) Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase are required for regulation of CD4+CD25+ T cell development. J Immunol 176:3958-65 |
| Kisseleva, Tatiana; Song, Li; Vorontchikhina, Marina et al. (2006) NF-kappaB regulation of endothelial cell function during LPS-induced toxemia and cancer. J Clin Invest 116:2955-63 |
| Fanzo, Jessica C; Yang, Wen; Jang, So Young et al. (2006) Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity. J Clin Invest 116:703-14 |
| Vuong, Bao Q; Arenzana, Teresita L; Showalter, Brian M et al. (2004) SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome. Mol Cell Biol 24:9092-101 |
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