Abstract

The objective of the Administrative core is to manage and coordinate the financial and support functions of the overall program. The Administrative Core will be directed by Kathryn V. Holmes, PhD, Principal Investigator of this Program Project Grant. Dr. Holmes will spend 5% of her effort directing this core, overseeing and coordinating the scientific aspects of the entire Program Project Grant. She will be responsible for submission of progress reports and will oversee the financial management of the grant. Dr. Holmes will be assisted in these efforts by Thomas Shallow, Administrator for Microbiology in the University of Colorado Health Sciences Center, who will serve Mr. Shallow will be responsible for the administrative and financial management of to the Program Manager, the Professional Research Assistant will assist Dr. Holmes scientific aspects of the program. the Department of as Program Manager. the project. In addition in managing the

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI059576-04
Application #
7454401
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
4
Fiscal Year
2007
Total Cost
$334,145
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Zhou, Bin; Pearce, Melissa B; Li, Yan et al. (2013) Asparagine substitution at PB2 residue 701 enhances the replication, pathogenicity, and transmission of the 2009 pandemic H1N1 influenza A virus. PLoS One 8:e67616
Zhou, Bin; Wentworth, David E (2012) Influenza A virus molecular virology techniques. Methods Mol Biol 865:175-92
Funk, C Joel; Wang, Jieru; Ito, Yoko et al. (2012) Infection of human alveolar macrophages by human coronavirus strain 229E. J Gen Virol 93:494-503
Chen, Lanfen; Chen, Zhangguo; Baker, Kristi et al. (2012) The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity 37:930-46
Zhou, Bin; Li, Yan; Speer, Scott D et al. (2012) Engineering temperature sensitive live attenuated influenza vaccines from emerging viruses. Vaccine 30:3691-702
Zhou, Bin; Jerzak, Greta; Scholes, Derek T et al. (2011) Reverse genetics plasmid for cloning unstable influenza A virus gene segments. J Virol Methods 173:378-83
Zhou, Bin; Li, Yan; Halpin, Rebecca et al. (2011) PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice. J Virol 85:357-65
Peng, Guiqing; Sun, Dawei; Rajashankar, Kanagalaghatta R et al. (2011) Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor. Proc Natl Acad Sci U S A 108:10696-701
Osborne, Christina; Cryan, Paul M; O'Shea, Thomas J et al. (2011) Alphacoronaviruses in New World bats: prevalence, persistence, phylogeny, and potential for interaction with humans. PLoS One 6:e19156
Zhou, Bin; Li, Yan; Belser, Jessica A et al. (2010) NS-based live attenuated H1N1 pandemic vaccines protect mice and ferrets. Vaccine 28:8015-25

Showing the most recent 10 out of 39 publications