The overall goal of providing administrative support for the proposed program project will beimplemented by the core through functions in several areas.1. Expenditures. The administration core will prepare personnel action forms and purchaseorders for Project 2 and Core B, all of which are located at Boston Medical Center. The core willmaintain a 'shadow' accounting of all grant expenditures for Project 2 and Core B.2. Accounting. The administration core will reconcile expenditures for Project 2 and Core Bwith Boston Medical Center financial reports and provide monthly statements to Dr. Rothsteinregarding remaining funds. The administration core will also obtain lists of expenditures from Dr.Chiles in connection with Project 1 and financial statements from Boston College, reconcile the twoand provide monthly statements to Dr. Chiles regarding remaining funds. The administrationcore/principal investigator will review all expenditures in connection with the program project, includingthose pertaining to Project 1 located at Boston College, to insure that expenditures are in all casesappropriate and within budgetary guidelines. The administration core will also assemble financialinformation for use in annual progress reports.3. Program Integration. The administrative core will assist in the preparation of monthlyreports concerning Projects 1 and 2 and Core B, and will disseminate these reports to project leaders.The administrative core will schedule monthly meetings of the project leaders (program executivecommittee). As part of these monthly meetings the project leaders will meet with Ms. Zenahlik (CoreB) to assess the isolation, purification, and delivery of B-1 and B-2 cells and to address anydeficiencies in sorting efficiency and/or other problems in B cell recovery and delivery to investigators.The administrative core will schedule biweekly meetings involving all staff and will make allarrangements for location, display equipment, and food/beverage. All research-in-progress will bediscussed at these biweekly meetings according to an agenda set by the principal investigator, whowill chair these meetings and carefully review research reports. At these research-in-progressmeetings the development of TAT fusion proteins, retroviral vectors, etc, will be evaluated todetermine if procedural changes are needed. This discussions will facilitate exhanges of personneland reagents so that all research goals are met in an efficient and timely manner.4. External Advisory Committee. The administration core will arrange for annual vists toBoston by members of the External Advisory Committee (Drs. E.C. Snow and R.R. Hardy, seeletters). This will entail scheduling visits; arranging transportation lodging and meals; reserving aconference room with appropriate display equipment; preparing scientific material for distribution atthe annual meeting; and preparing a final report at the end of each annual meeting. The externaladvisory committee will evaluate data generated during the past year, research plans for theupcoming year, and implementation of the data sharing protocol. The external advisory committeewill meet with all personnel involved in the program to hear research reports, and will also meetseparately with the project leaders (executive committee) to facilitate a frank assessment of researchprogress and plans.5. Mason. The administration core will interface with all regulatory groups that play a role in thework proposed for this program project, including, prominently, the Institutional Animal Care and UseCommittee (IACUC) and the Laboratory Animal Science Center (LASC). The administration core willcommunicate directly with the Jackson Laboratory (Bar Harbor, ME) to insure that deliveries of miceare on schedule and not interrupted. The administration core will also interface with the InstitutionalBiosafety Committee (IBC); the Radiation Protection Office (RPO); and the Biosafety Office. Theadministration core will interface with similar bodies at Boston College on behalf of Project 1.6. Reports. The administration core will prepare manuscripts, progress reports, and competitiveand non-competitive grant renewals in connection with this program project. The administration corewill coordinate all correspondence and e-mail communications regarding these items.7. Data Sharing. The administration core will oversee the construction of a public website toassist in dissemination of protocols and data generated in connection with this proposed programproject. The administration core will also forward to GenBank any sequences that through datasharing will be put in the public domain.
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