The Administrative Core (Core A) will function as the administrative and organizational structure thatcoordinates the activities of the Program Project Grant (PPG) and facilitates its scientific mission. The goalof the Administrative Core is to ensure a programmatic, multidisciplinary focus, facilitate intra- andextra-center communications, and relieve Project Leaders (PLs) and Core Directors of the commonadministrative activities required to manage a PPG of this size. Dr. Brasier, Core Director, is anexperienced administrator who will oversee the day-to-day operations of the program including coordinatingthe regular Research in Progress meetings of project personnel and monthly meetings with the InternalAdvisory Committee (IAC). As Administrative Core Leader, Dr. Brasier will be responsible for evaluation ofproject activities (in conjunction with the Advisory Committee) and will ensure timely progress towardsaccomplishing the goals and aims of the PPG, ensure continuing interactions among the various componentsand will assure adherence of the individual components to the central theme of the program. The IAC willconsist of PLs and 5 highly recognized campus leaders: Drs. Halpert (Director of the NIEHS Center inEnvironmental Toxicology), Norbert Roberts (Director of the Infectious Disease Division), Larry Stanberry(Chairman, Dept. Pediatrics and Director of the Sealy Center for Vaccine Development), Bruce Luxon(Director of the Bioinformatics Program), and Sankar Mitra (Senior Scientist, Sealy Center for MolecularSciences). The Administrative Core will be responsible for scheduling annual meetings with the ExternalAdvisory Committee (EAC) including making travel arrangements and hotel accommodations. Fouroutstanding investigators have volunteered for the EAC: Drs. David Peden (UNC Chapel Hill), David Proud(University of Calgary), Steven Kunkel (University of Michigan) and Paul Nobel (Yale University). Inaddition, the Administrative Core will ensure integration of PPG activities and seminars with those of theNHLBI Proteomics Center, Sealy Center for Environmental Health and Medicine, and the Office of PediatricClinical Research when appropriate. The Administrative Core will further assist the PLs and Core Directorsby serving as a liason to the NIH and to the EAC. These activities free the Project Leaders and CoreDirectors to pursue their scientific tasks and objectives.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI062885-04
Application #
7657064
Study Section
Special Emphasis Panel (ZAI1-GB-I (S1))
Project Start
2008-04-01
Project End
2010-03-31
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
4
Fiscal Year
2008
Total Cost
$76,380
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Type
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Tian, Bing; Widen, Steven G; Yang, Jun et al. (2018) The NF?B subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells. J Biol Chem 293:16528-16545
Graber, Ted G; Rawls, Brandy L; Tian, Bing et al. (2018) Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. Exp Gerontol 106:88-100
Tian, Bing; Yang, Jun; Zhao, Yingxin et al. (2018) Central Role of the NF-?B Pathway in the Scgb1a1-Expressing Epithelium in Mediating Respiratory Syncytial Virus-Induced Airway Inflammation. J Virol 92:
Tian, Bing; Hosoki, Koa; Liu, Zhiqing et al. (2018) Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling. J Allergy Clin Immunol :
Wang, Ruoxi; Hao, Wenjing; Pan, Lang et al. (2018) The roles of base excision repair enzyme OGG1 in gene expression. Cell Mol Life Sci 75:3741-3750
Tian, Bing; Liu, Zhiqing; Yang, Jun et al. (2018) Selective Antagonists of the Bronchiolar Epithelial NF-?B-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation. Cell Rep 23:1138-1151
Ba, Xueqing; Boldogh, Istvan (2018) 8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions. Redox Biol 14:669-678
Visnes, Torkild; Cázares-Körner, Armando; Hao, Wenjing et al. (2018) Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science 362:834-839
Ochoa, Lorenzo F; Kholodnykh, Alexander; Villarreal, Paula et al. (2018) Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing. Sci Rep 8:13348
Liu, Zhiqing; Tian, Bing; Chen, Haiying et al. (2018) Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem 151:450-461

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