Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
1P01AI066287-01A1
Application #
7166861
Study Section
Special Emphasis Panel (ZAI1-RB-A (M1))
Project Start
2006-06-01
Project End
2011-08-31
Budget Start
2006-06-01
Budget End
2007-08-31
Support Year
1
Fiscal Year
2006
Total Cost
$181,483
Indirect Cost
Name
Novartis Vaccines and Diagnostics, Inc.
Department
Type
DUNS #
046866463
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Shen, Xiaoying; Bogers, Willy M; Yates, Nicole L et al. (2017) Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques. J Virol 91:
Bogers, Willy M J M; Barnett, Susan W; Oostermeijer, Herman et al. (2017) Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site. J Virol 91:
Bruun, Tim-Henrik; Grassmann, Veronika; Zimmer, Benjamin et al. (2017) Mammalian cell surface display for monoclonal antibody-based FACS selection of viral envelope proteins. MAbs 9:1052-1064
Liang, Frank; Lindgren, Gustaf; Sandgren, Kerrie J et al. (2017) Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake. Sci Transl Med 9:
Vassell, Russell; He, Yong; Vennakalanti, Prasad et al. (2015) Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein. PLoS One 10:e0128562
Bogers, Willy M; Oostermeijer, Herman; Mooij, Petra et al. (2015) Potent immune responses in rhesus macaques induced by nonviral delivery of a self-amplifying RNA vaccine expressing HIV type 1 envelope with a cationic nanoemulsion. J Infect Dis 211:947-55
Tuero, Iskra; Mohanram, Venkatramanan; Musich, Thomas et al. (2015) Mucosal B Cells Are Associated with Delayed SIV Acquisition in Vaccinated Female but Not Male Rhesus Macaques Following SIVmac251 Rectal Challenge. PLoS Pathog 11:e1005101
Brito, Luis A; Chan, Michelle; Shaw, Christine A et al. (2014) A cationic nanoemulsion for the delivery of next-generation RNA vaccines. Mol Ther 22:2118-29
Kassa, Aemro; Dey, Antu K; Sarkar, Pampi et al. (2013) Stabilizing exposure of conserved epitopes by structure guided insertion of disulfide bond in HIV-1 envelope glycoprotein. PLoS One 8:e76139
Dey, Antu K; Burke, Brian; Sun, Yide et al. (2012) Elicitation of neutralizing antibodies directed against CD4-induced epitope(s) using a CD4 mimetic cross-linked to a HIV-1 envelope glycoprotein. PLoS One 7:e30233

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