The Administrative Core, under the direction of Project Manager Randall Deck, will be headquartered atChiron Corporation (Chiron) - the applicant organization. Upon approval of this grant application, the corewill be initially responsible for facilitating formal written agreements between Chiron and each consortiumparticipant in order to meet the scientific, administrative, financial, and reporting requirements of the grant,including those necessary to ensure compliance with all applicable Federal regulations and policies. Thecontracts will include all requirements referenced in the NIH Grants Policy Statement regarding consortiumagreements. The Administrative Core will be responsible for disbursement of grant funds, as required, toconsortium participants. In order to provide a forum to facilitate the coordination of research activities, thedesign of experiments related to the project, the review of research progress and budgetary issues, theAdministrative Core will organize (1) quarterly teleconferences (more frequently if required) with Project/CoreLeaders and (2) annual face-to-face meetings at NIAID-sponsored AIDS meetings. The Administrative Corewill request Project/Core Leaders to submit brief written quarterly research updates which will be distributedto all participants prior to each meeting. In addition, agenda items for each teleconference and annualmeeting will be outlined and distributed in advance, and summaries of each meeting will be recorded anddisseminated to the project participants by the Administrative Core. Meeting summaries and quarterlywritten reports will also form the basis of progress reports to be submitted to the NIH by this core. TheAdministrative Core will also establish and maintain a secure web site in order to provide easy access for allparticipants to meeting schedules, agendas and research reports. The Administrative Core will provide theword-processing and graphic art support required for final manuscript submissions. This core will also beresponsible for page charges and other costs related to manuscript submission as well as distribution ofpreprints and reprints.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI066287-03
Application #
7683415
Study Section
Special Emphasis Panel (ZAI1-RB-A (M1))
Project Start
2008-09-01
Project End
2011-08-31
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
3
Fiscal Year
2008
Total Cost
$225,750
Indirect Cost
Name
Novartis Vaccines and Diagnostics, Inc.
Department
Type
DUNS #
046866463
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Shen, Xiaoying; Bogers, Willy M; Yates, Nicole L et al. (2017) Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques. J Virol 91:
Bogers, Willy M J M; Barnett, Susan W; Oostermeijer, Herman et al. (2017) Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site. J Virol 91:
Bruun, Tim-Henrik; Grassmann, Veronika; Zimmer, Benjamin et al. (2017) Mammalian cell surface display for monoclonal antibody-based FACS selection of viral envelope proteins. MAbs 9:1052-1064
Liang, Frank; Lindgren, Gustaf; Sandgren, Kerrie J et al. (2017) Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake. Sci Transl Med 9:
Vassell, Russell; He, Yong; Vennakalanti, Prasad et al. (2015) Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein. PLoS One 10:e0128562
Bogers, Willy M; Oostermeijer, Herman; Mooij, Petra et al. (2015) Potent immune responses in rhesus macaques induced by nonviral delivery of a self-amplifying RNA vaccine expressing HIV type 1 envelope with a cationic nanoemulsion. J Infect Dis 211:947-55
Tuero, Iskra; Mohanram, Venkatramanan; Musich, Thomas et al. (2015) Mucosal B Cells Are Associated with Delayed SIV Acquisition in Vaccinated Female but Not Male Rhesus Macaques Following SIVmac251 Rectal Challenge. PLoS Pathog 11:e1005101
Brito, Luis A; Chan, Michelle; Shaw, Christine A et al. (2014) A cationic nanoemulsion for the delivery of next-generation RNA vaccines. Mol Ther 22:2118-29
Kassa, Aemro; Dey, Antu K; Sarkar, Pampi et al. (2013) Stabilizing exposure of conserved epitopes by structure guided insertion of disulfide bond in HIV-1 envelope glycoprotein. PLoS One 8:e76139
Dey, Antu K; Burke, Brian; Sun, Yide et al. (2012) Elicitation of neutralizing antibodies directed against CD4-induced epitope(s) using a CD4 mimetic cross-linked to a HIV-1 envelope glycoprotein. PLoS One 7:e30233

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