The Administrative Core, under the direction of Project Manager Randall Deck, will be headquartered at Chiron Corporation (Chiron) - the applicant organization. Upon approval of this grant application, the core will be initially responsible for facilitating formal written agreements between Chiron and each consortium participant in order to meet the scientific, administrative, financial, and reporting requirements of the grant, including those necessary to ensure compliance with all applicable Federal regulations and policies. The contracts will include all requirements referenced in the NIH Grants Policy Statement regarding consortium agreements. The Administrative Core will be responsible for disbursement of grant funds, as required, to consortium participants. In order to provide a forum to facilitate the coordination of research activities, the design of experiments related to the project, the review of research progress and budgetary issues, the Administrative Core will organize (1) quarterly teleconferences (more frequently if required) with Project/Core Leaders and (2) annual face-to-face meetings at NIAID-sponsored AIDS meetings. The Administrative Core will request Project/Core Leaders to submit brief written quarterly research updates which will be distributed to all participants prior to each meeting. In addition, agenda items for each teleconference and annual meeting will be outlined and distributed in advance, and summaries of each meeting will be recorded and disseminated to the project participants by the Administrative Core. Meeting summaries and quarterly written reports will also form the basis of progress reports to be submitted to the NIH by this core. The Administrative Core will also establish and maintain a secure web site in order to provide easy access for all participants to meeting schedules, agendas and research reports. The Administrative Core will provide the word-processing and graphic art support required for final manuscript submissions. This core will also be responsible for page charges and other costs related to manuscript submission as well as distribution of preprints and reprints.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI066287-05
Application #
8130715
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
2013-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
5
Fiscal Year
2010
Total Cost
$285,390
Indirect Cost
Name
Novartis Vaccines and Diagnostics, Inc.
Department
Type
DUNS #
046866463
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Shen, Xiaoying; Bogers, Willy M; Yates, Nicole L et al. (2017) Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques. J Virol 91:
Bogers, Willy M J M; Barnett, Susan W; Oostermeijer, Herman et al. (2017) Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site. J Virol 91:
Bruun, Tim-Henrik; Grassmann, Veronika; Zimmer, Benjamin et al. (2017) Mammalian cell surface display for monoclonal antibody-based FACS selection of viral envelope proteins. MAbs 9:1052-1064
Liang, Frank; Lindgren, Gustaf; Sandgren, Kerrie J et al. (2017) Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake. Sci Transl Med 9:
Vassell, Russell; He, Yong; Vennakalanti, Prasad et al. (2015) Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein. PLoS One 10:e0128562
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Tuero, Iskra; Mohanram, Venkatramanan; Musich, Thomas et al. (2015) Mucosal B Cells Are Associated with Delayed SIV Acquisition in Vaccinated Female but Not Male Rhesus Macaques Following SIVmac251 Rectal Challenge. PLoS Pathog 11:e1005101
Brito, Luis A; Chan, Michelle; Shaw, Christine A et al. (2014) A cationic nanoemulsion for the delivery of next-generation RNA vaccines. Mol Ther 22:2118-29
Kassa, Aemro; Dey, Antu K; Sarkar, Pampi et al. (2013) Stabilizing exposure of conserved epitopes by structure guided insertion of disulfide bond in HIV-1 envelope glycoprotein. PLoS One 8:e76139
Dey, Antu K; Burke, Brian; Sun, Yide et al. (2012) Elicitation of neutralizing antibodies directed against CD4-induced epitope(s) using a CD4 mimetic cross-linked to a HIV-1 envelope glycoprotein. PLoS One 7:e30233

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