Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
1P01AI067921-01
Application #
7071317
Study Section
Special Emphasis Panel (ZAI1-AR-M (S1))
Project Start
2005-09-01
Project End
2009-03-31
Budget Start
2005-09-01
Budget End
2007-03-31
Support Year
1
Fiscal Year
2006
Total Cost
$249,095
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
PedrĂ³-Rosa, Laura; Buckner, Frederick S; Ranade, Ranae M et al. (2015) Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening. J Biomol Screen 20:122-30
Koh, Cho Yeow; Kim, Jessica E; Napoli, Alberto J et al. (2013) Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol Biochem Parasitol 189:26-32
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Koh, Cho Yeow; Kim, Jessica E; Shibata, Sayaka et al. (2012) Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection. Structure 20:1681-91
Zucker, Frank H; Kim, Hae Young; Merritt, Ethan A (2012) PROSPERO: online prediction of crystallographic success from experimental results and sequence. J Appl Crystallogr 45:598-602
Johnson, Steven M; Murphy, Ryan C; Geiger, Jennifer A et al. (2012) Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity. J Med Chem 55:2416-26
Larson, Eric T; Kim, Jessica E; Napuli, Alberto J et al. (2012) Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. Acta Crystallogr D Biol Crystallogr 68:1194-200
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