PedrĂ³-Rosa, Laura; Buckner, Frederick S; Ranade, Ranae M et al. (2015) Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening. J Biomol Screen 20:122-30
|
Koh, Cho Yeow; Kim, Jessica E; Napoli, Alberto J et al. (2013) Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol Biochem Parasitol 189:26-32
|
Ranade, Ranae M; Gillespie, J Robert; Shibata, Sayaka et al. (2013) Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target. Antimicrob Agents Chemother 57:3021-8
|
Shibata, Sayaka; Gillespie, J Robert; Ranade, Ranae M et al. (2012) Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem 55:6342-51
|
Larson, Eric T; Ojo, Kayode K; Murphy, Ryan C et al. (2012) Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J Med Chem 55:2803-10
|
Koh, Cho Yeow; Kim, Jessica E; Shibata, Sayaka et al. (2012) Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection. Structure 20:1681-91
|
Zucker, Frank H; Kim, Hae Young; Merritt, Ethan A (2012) PROSPERO: online prediction of crystallographic success from experimental results and sequence. J Appl Crystallogr 45:598-602
|
Johnson, Steven M; Murphy, Ryan C; Geiger, Jennifer A et al. (2012) Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity. J Med Chem 55:2416-26
|
Larson, Eric T; Kim, Jessica E; Napuli, Alberto J et al. (2012) Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. Acta Crystallogr D Biol Crystallogr 68:1194-200
|
Shibata, Sayaka; Zhang, Zhongsheng; Korotkov, Konstantin V et al. (2011) Screening a fragment cocktail library using ultrafiltration. Anal Bioanal Chem 401:1585-91
|
Showing the most recent 10 out of 33 publications