This Core is intended to: 1. permit rapid and safe exchange of germline mutant mice between La Jolla and? Osaka as frozen embryos, circumventing the delay imposed by quarantine; 2. secure the valuable strains? created using ENU; 3. provide for the rescue of strains with low fertility and accelerate the fixation of? mutations that can only be fixed by inbreeding, given that the MCMV screen is lethal to homozygotes; 4.? provide for the distribution of mutant strains to the scientific community at large by expanding and shipping? homozygous stocks to the MMRRC. This Core will be run using techniques that we have established and? have used routinely, and requires no expenditure for equipment. It will be mirrored by a comparable Core in? Osaka, Japan, which will focus primarily upon items 1, 2, and 4 (above) to the exclusion of IVF. Neither? Core can function in the absence of the other, since embryos frozen in one Core must be re-derived in the? other, and vice versa. Hence they should each be viewed as separate but essential Cores for two of the? participating groups (in La Jolla and Osaka).
| Goto, Akira; Okado, Kiyoshi; Martins, Nelson et al. (2018) The Kinase IKK? Regulates a STING- and NF-?B-Dependent Antiviral Response Pathway in Drosophila. Immunity 49:225-234.e4 |
| Takahama, Michihiro; Fukuda, Mitsunori; Ohbayashi, Norihiko et al. (2017) The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses. Cell Rep 20:2944-2954 |
| Maeda, Kazuhiko; Akira, Shizuo (2017) Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells. Int Immunol 29:149-155 |
| Satoh, Takashi; Nakagawa, Katsuhiro; Sugihara, Fuminori et al. (2017) Identification of an atypical monocyte and committed progenitor involved in fibrosis. Nature 541:96-101 |
| Kozaki, Tatsuya; Komano, Jun; Kanbayashi, Daiki et al. (2017) Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. Proc Natl Acad Sci U S A 114:2681-2686 |
| Mager, Lukas Franz; Koelzer, Viktor Hendrik; Stuber, Regula et al. (2017) The ESRP1-GPR137 axis contributes to intestinal pathogenesis. Elife 6: |
| Mussabekova, Assel; Daeffler, Laurent; Imler, Jean-Luc (2017) Innate and intrinsic antiviral immunity in Drosophila. Cell Mol Life Sci 74:2039-2054 |
| Kuhn, Lauriane; Majzoub, Karim; Einhorn, Evelyne et al. (2017) Definition of a RACK1 Interaction Network in Drosophila melanogaster Using SWATH-MS. G3 (Bethesda) 7:2249-2258 |
| Lamiable, Olivier; Arnold, Johan; de Faria, Isaque Joao da Silva et al. (2016) Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity. J Virol 90:5415-5426 |
| Marques, João T; Imler, Jean-Luc (2016) The diversity of insect antiviral immunity: insights from viruses. Curr Opin Microbiol 32:71-76 |
Showing the most recent 10 out of 87 publications
