Core A consists of two components: 1) the Administrative Component, that will provide overall administrative oversight for the Program;and 2) the Biostatistics Compoonent, that will conduct biostatistical analysis and data management activities. The primary function of the Administrative Component will be to facilitate scientific interactions between all of the investigators of this program project application. The Administrative Component will oversee the conduct of program meetings, monthly teleconference calls, and joint activities. This component will also provide support for the preparation of scientific reports and presentation of research data, and will be responsible for facilitating the developent of intellectual property values from the discoveries of individual investigators on this program project. The primary goal of the Biostatistics Component is to strenghten the research efforts and introduce statistical rigor in the proposed studies. This goal will be accomplished by: 1) providing statistical analysis services for data analysis, design of experiments, and manuscript preparation;2) establishing and maintaining appropriate databases, data management and data analysis capabilities and developing software/algorithms;3) coordinating with the other cores on the collection and evaluation of their data;4) providing one-on-one training in biostatistics methods and data management to investigators, postdoctoral fellows, and graduate students.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI080192-02
Application #
7939589
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
2
Fiscal Year
2009
Total Cost
$97,154
Indirect Cost
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Wieland, Andreas; Kamphorst, Alice O; Adsay, N Volkan et al. (2018) T cell receptor sequencing of activated CD8 T cells in the blood identifies tumor-infiltrating clones that expand after PD-1 therapy and radiation in a melanoma patient. Cancer Immunol Immunother 67:1767-1776
Youngblood, Ben; Hale, J Scott; Kissick, Haydn T et al. (2017) Effector CD8 T cells dedifferentiate into long-lived memory cells. Nature 552:404-409
Kamphorst, Alice O; Wieland, Andreas; Nasti, Tahseen et al. (2017) Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science 355:1423-1427
Bally, Alexander P R; Tang, Yan; Lee, Joshua T et al. (2017) Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory. J Immunol 198:205-217
Im, Se Jin; Hashimoto, Masao; Gerner, Michael Y et al. (2016) Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature 537:417-421
Kamphorst, Alice O; Araki, Koichi; Ahmed, Rafi (2015) Beyond adjuvants: immunomodulation strategies to enhance T cell immunity. Vaccine 33 Suppl 2:B21-8
Chetty, Shivan; Govender, Pamla; Zupkosky, Jennifer et al. (2015) Co-infection with Mycobacterium tuberculosis impairs HIV-Specific CD8+ and CD4+ T cell functionality. PLoS One 10:e0118654
Porichis, Filippos; Hart, Meghan G; Zupkosky, Jennifer et al. (2014) Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions. J Virol 88:2508-18
Penaloza-MacMaster, Pablo; Kamphorst, Alice O; Wieland, Andreas et al. (2014) Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. J Exp Med 211:1905-18
Xiao, Yanping; Yu, Sanhong; Zhu, Baogong et al. (2014) RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med 211:943-59

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