The administrative core of this PPG, led by Dr. Kenneth Bayles, will provide the organizational structure for the entire program project and will give leadership, oversight, and direction for the individual projects and cores. The first specific aim of this core, to set and implement the programmatic goals for the PPG, will be achieved through regular interactions with each of the participants in this PPG to monitor the progress and reinforce the specific aims of each project.
The second aim will be to assure that the participants of this PPG are communicating effectively by organizing regular meetings to promote the exchange of ideas and to ensure that off-campus participants are fully integrated into this project. Developing the scientific program will be the third aim focusing primarily on pursuing additional funding opportunities that will complement and foster the continued growth of our program.
The fourth aim will be to maintain a system for fiscal accountability and resource allocation, ensuring that all budgetary issues related to this PPG are handled appropriately by trained personnel who are experienced with NIH and UNMC policies related to grants administration. The fifth and final aim will be to offer statistical support for all projects in the planning of experiments and interpretation of results. This support will be coordinated by Dr. Fang Yu in the Department of Biostatistics at the University of Nebraska Medical Center, who will participate in regular meetings with the members of this PPG. The successful implementation of these specific aims will form a solid foundation of administrative support needed by each of the scientific projects in this PPG and will help to assure the continued success of our program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
2P01AI083211-06
Application #
8742802
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Nebraska Medical Center
Department
Type
DUNS #
City
Omaha
State
NE
Country
United States
Zip Code
68198
Svechkarev, Denis; Sadykov, Marat R; Bayles, Kenneth W et al. (2018) Ratiometric Fluorescent Sensor Array as a Versatile Tool for Bacterial Pathogen Identification and Analysis. ACS Sens 3:700-708
Yamada, Kelsey J; Heim, Cortney E; Aldrich, Amy L et al. (2018) Arginase-1 Expression in Myeloid Cells Regulates Staphylococcus aureus Planktonic but Not Biofilm Infection. Infect Immun 86:
King, Alyssa N; Borkar, Samiksha; Samuels, David J et al. (2018) Guanine limitation results in CodY-dependent and -independent alteration of Staphylococcus aureus physiology and gene expression. J Bacteriol :
Mlynek, Kevin D; Sause, William E; Moormeier, Derek E et al. (2018) Nutritional Regulation of the Sae Two-Component System by CodY in Staphylococcus aureus. J Bacteriol 200:
Yamada, Kelsey J; Kielian, Tammy (2018) Biofilm-Leukocyte Cross-Talk: Impact on Immune Polarization and Immunometabolism. J Innate Immun :1-9
Bhinderwala, Fatema; Lonergan, Samantha; Woods, Jade et al. (2018) Expanding the Coverage of the Metabolome with Nitrogen-Based NMR. Anal Chem 90:4521-4528
Heim, Cortney E; Vidlak, Debbie; Odvody, Jessica et al. (2018) Human prosthetic joint infections are associated with myeloid-derived suppressor cells (MDSCs): Implications for infection persistence. J Orthop Res 36:1605-1613
Gries, Casey M; Kielian, Tammy (2017) Staphylococcal Biofilms and Immune Polarization During Prosthetic Joint Infection. J Am Acad Orthop Surg 25 Suppl 1:S20-S24
Krute, Christina N; Rice, Kelly C; Bose, Jeffrey L (2017) VfrB Is a Key Activator of the Staphylococcus aureus SaeRS Two-Component System. J Bacteriol 199:
Moormeier, Derek E; Bayles, Kenneth W (2017) Staphylococcus aureus biofilm: a complex developmental organism. Mol Microbiol 104:365-376

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