The Harvard-wide Program on Antibiotic Resistance (HPAR) represents a tightly knit set of collaborative research projects to address one of the leading public health issues in the US -- the spread of antibiotic resistant Staphylococcus aureus as a leading cause of serious infection in the community as well as in hospitals. Advanced by a cohesive, multi-disciplinary group of clinical, basic and translational scientists, the theme of this Program Project proposal is to """"""""Derive new approaches for combating MRSA infection, and limiting the development and spread of antibiotic resistance."""""""" The expertise of this team ranges from high throughput screening/follow up chemistry, biochemistry, molecular biology/genetics, and molecular pathogenesis to clinical microbiology. The investigators are all among leaders in their respective fields, and bring the perspectives and assets of institutions spanning Harvard University - Massachusetts General Hospital, Harvard Medical School, Harvard College, and Schepens Eye Research Institute - to bear. The goal of this Program Project is to capitalize on multi-disciplinary perspectives, and to take both hypothesis driven and discovery approaches, to advance a better understanding of the development (Subproject 1: Hooper) and spread (Subproject 2: Gilmore) of antibiotic resistance in S. aureus;and to identify novel compounds, targets and pathways to compromise the microbe in its interaction with the host (Subproject 3: walker;Subproject 4: Ausubel/Mylonakis [both in collaboration with Hooper and Gilmore]). The entire project is held together, with each project being leveraged by the others, by the Administrative Core (Core A), which will be led by a P1 with considerable administrative experience. The HPAR is specifically designed to synergize and leverage internal and external initiatives, including the Harvard-wide Microbial sciences Initiative and the Catalyst Clinical and Translational Science Center, and the NIAID NARSA program. ran o'"""""""". =?. 7""""""""o vii '-? FD'

Public Health Relevance

Staphylococcusaureus;especiallymethicillinresistant(MRSA)strains;haveemergedasleadingcausesoflifethreateninginfectioninthehospitalandinthecommunity.WhiletheMRSAproblemisalarming;ithasbecomecriticalastheresultoftheintroductionoffrankvancomycinresistance.Therenowhavebeen9welldocumentedcasesoftransferofvancomycinresistancefromenterococcitoMRSAintheUS.ThisProgramProjectisdesignedtoidentifynewcompoundsforcombatingS.aureusinfectionandfortifyingthehostimmuneresponse;thatideallywillnotbecompromisedbyexistingbacterialeffluxsystemsoracquiredresistances.6

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
7P01AI083214-02
Application #
8091754
Study Section
Special Emphasis Panel (ZAI1-EL-M (M1))
Program Officer
Huntley, Clayton C
Project Start
2009-09-01
Project End
2011-08-31
Budget Start
2010-07-01
Budget End
2010-08-31
Support Year
2
Fiscal Year
2009
Total Cost
$1,316,631
Indirect Cost
Name
Massachusetts Eye and Ear Infirmary
Department
Type
DUNS #
073825945
City
Boston
State
MA
Country
United States
Zip Code
02114
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Johnston, Tatiana; Van Tyne, Daria; Chen, Roy F et al. (2018) Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin-resistant Staphylococcus aureus. Sci Rep 8:7062
Bispo, Paulo J M; Davoudi, Samaneh; Sahm, Matthew L et al. (2018) Rapid Detection and Identification of Uveitis Pathogens by Qualitative Multiplex Real-Time PCR. Invest Ophthalmol Vis Sci 59:582-589
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