Managing and coordinating funding and communication between 5 investigators located at 3 different institutions (Weiss and Roose at UCSF; Kuriyan and Groves at UC Berkeley; and, Chakraborty at MIT), as well as a new proteomics core involving another investigator at a fourth institution (Salomon at Brown U.) is a complex and time consuming process. Therefore, we are requesting that an Administrative Core be added to this research program. The Core will be led by Dr. Arthur Weiss, who is also the PI of this P01 application. He will be assisted by a research analyst (RA) and an administrative assistant (AA) to optimally coordinate the administrative responsibilities and flow of information between institutions and investigators. The overall goal of the administrative core will be to improve efficiency and quality of the administration of this proposal. The core will be responsible for 1) coordinating grant funds management, allocation, and appropriate uses; 2) coordinating communication and information flow between institutions and investigators; 3) and, coordinating monthly and quarterly meetings for each project and a yearly annual on site meeting.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI091580-08
Application #
9517654
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
8
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Courtney, Adam H; Lo, Wan-Lin; Weiss, Arthur (2018) TCR Signaling: Mechanisms of Initiation and Propagation. Trends Biochem Sci 43:108-123
Shah, Neel H; Löbel, Mark; Weiss, Arthur et al. (2018) Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen. Elife 7:
Cantor, Aaron J; Shah, Neel H; Kuriyan, John (2018) Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites. Proc Natl Acad Sci U S A 115:E7303-E7312
Lo, Wan-Lin; Shah, Neel H; Ahsan, Nagib et al. (2018) Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT. Nat Immunol 19:733-741
Pielak, Rafal M; O'Donoghue, Geoff P; Lin, Jenny J et al. (2017) Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination. Proc Natl Acad Sci U S A 114:12190-12195
Courtney, Adam H; Amacher, Jeanine F; Kadlecek, Theresa A et al. (2017) A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45. Mol Cell 67:498-511.e6
Ahsan, Nagib; Belmont, Judson; Chen, Zhuo et al. (2017) Highly reproducible improved label-free quantitative analysis of cellular phosphoproteome by optimization of LC-MS/MS gradient and analytical column construction. J Proteomics 165:69-74
Ahsan, Nagib; Salomon, Arthur R (2017) Quantitative Phosphoproteomic Analysis of T-Cell Receptor Signaling. Methods Mol Biol 1584:369-382
Ashouri, Judith F; Weiss, Arthur (2017) Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells. J Immunol 198:657-668
Vercoulen, Yvonne; Kondo, Yasushi; Iwig, Jeffrey S et al. (2017) A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife 6:

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