The administrative core will be responsible for all administration of this program. The program proposed here contains 3 independent yet linked projects and 2 scientific cores that will develop 3 different strategies to deliver non-coding RNAs capable of transcriptionally suppressing and directing the excising of HIV-1 or the CCRS chemokine co-receptor to either HIV-1 infected cells or those immune cells targeted for infection by HIV-1. The administrative core will function by: Overseeing the fiscal, administrative, and legal responsibilities for the entire program;fostering interactions between the different investigators and their respective projects;and assuming responsibility for confirming that all research is conducted in an optimal and ethical manner. As such the role of the administrative core is integral to the success of this program.
The specific aims of the administrative core are: (1) Coordinate administrative and fiscal requirements of the program. (2) Supervise and foster the scientific progress of the program. (3) Oversee the dissemination and sharing of the results from each project within the program.
The administrative core will oversee the fiscal, administrative, and legal responsibilities for the entire program with the aim of fostering interactions between the different investigators and their respective projects and assuring that all research is conducted in an optimal and ethical manner.
| Zhou, Jiehua; Lazar, Daniel; Li, Haitang et al. (2018) Receptor-targeted aptamer-siRNA conjugate-directed transcriptional regulation of HIV-1. Theranostics 8:1575-1590 |
| Astakhova, Kira; Ray, Roslyn; Taskova, Maria et al. (2018) ""Clicking"" Gene Therapeutics: A Successful Union of Chemistry and Biomedicine for New Solutions. Mol Pharm 15:2892-2899 |
| Shevchenko, Galina; Morris, Kevin V (2018) All I's on the RADAR: role of ADAR in gene regulation. FEBS Lett 592:2860-2873 |
| Shrivastava, Surya; Charlins, Paige; Ackley, Amanda et al. (2018) Stable Transcriptional Repression and Parasitism of HIV-1. Mol Ther Nucleic Acids 12:12-18 |
| Johnsson, Per; Lister, Nicholas; Shevchenko, Galina et al. (2017) Reply to Liu et al.: Yin and yang of PTEN regulation. Proc Natl Acad Sci U S A 114:E10512-E10513 |
| Lister, Nicholas; Shevchenko, Galina; Walshe, James L et al. (2017) The molecular dynamics of long noncoding RNA control of transcription in PTEN and its pseudogene. Proc Natl Acad Sci U S A 114:9942-9947 |
| Hewson, Chris; Capraro, David; Burdach, Jon et al. (2016) Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability. Noncoding RNA Res 1:3-11 |
| Fortes, Puri; Morris, Kevin V (2016) Long noncoding RNAs in viral infections. Virus Res 212:1-11 |
| Hewson, Chris; Morris, Kevin V (2016) Form and Function of Exosome-Associated Long Non-coding RNAs in Cancer. Curr Top Microbiol Immunol 394:41-56 |
| Lazar, Daniel C; Morris, Kevin V; Saayman, Sheena M (2016) The emerging role of long non-coding RNAs in HIV infection. Virus Res 212:114-26 |
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