Abstract

This is a proposal for an interdisciplinary program for basic research in problems of skin biology and pathology. At present, this involves funded components as follow: 1. Analysis of biochemical and functional properties of the basic (mature) protein of stratum corneum with especial reference to how this protein relates to cellular morphology and to cutaneous disease in instances where keratohyalin is absent. 2. The analysis of structural and biochemical characteristics of inherited diseases of structural defects in collagen.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Program Projects (P01)
Project #
5P01AM021557-07
Application #
3092261
Study Section
(SRC)
Project Start
1978-12-01
Project End
1986-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Bunick, Christopher G; Presland, Richard B; Lawrence, Owen T et al. (2015) Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin II, Stratifin, and HSP27. J Invest Dermatol 135:1801-1809
Chatterjea, Sudeshna M; Resing, Katheryn A; Old, William et al. (2011) Optimization of filaggrin expression and processing in cultured rat keratinocytes. J Dermatol Sci 61:51-9
Fallon, Padraic G; Sasaki, Takashi; Sandilands, Aileen et al. (2009) A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat Genet 41:602-8
Presland, Richard B; Coulombe, Pierre A; Eckert, Richard L et al. (2004) Barrier function in transgenic mice overexpressing K16, involucrin, and filaggrin in the suprabasal epidermis. J Invest Dermatol 123:603-6
Fleckman, Philip; Brumbaugh, Steven (2002) Absence of the granular layer and keratohyalin define a morphologically distinct subset of individuals with ichthyosis vulgaris. Exp Dermatol 11:327-36
Presland, Richard B; Jurevic, Richard J (2002) Making sense of the epithelial barrier: what molecular biology and genetics tell us about the functions of oral mucosal and epidermal tissues. J Dent Educ 66:564-74
Pearton, David J; Dale, Beverly A; Presland, Richard B (2002) Functional analysis of the profilaggrin N-terminal peptide: identification of domains that regulate nuclear and cytoplasmic distribution. J Invest Dermatol 119:661-9
Presland, R B; Kuechle, M K; Lewis, S P et al. (2001) Regulated expression of human filaggrin in keratinocytes results in cytoskeletal disruption, loss of cell-cell adhesion, and cell cycle arrest. Exp Cell Res 270:199-213
Presland, R B; Tomic-Canic, M; Lewis, S P et al. (2001) Regulation of human profilaggrin promoter activity in cultured epithelial cells by retinoic acid and glucocorticoids. J Dermatol Sci 27:192-205
Presland, R B; Boggess, D; Lewis, S P et al. (2000) Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris. J Invest Dermatol 115:1072-81

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