Abstract

The program consists of four major areas: 1) Structural and functional studies of connective tissue, serum and membrane proteins including cartilage constituents and fibronectin. 2) Humoral immunity including the structure, function, biosynthesis and genetic control of immunoglobulins and factors involved in the regulation of antibody synthesis. In parallel and complementing this, there is an active program devoted to the structure of certain complement components and their interaction with cellular receptors. Clinically, these studies converge on patients with immune complex diseases and patients with lymphoproliferative or plasma cell disorders. 3) Cellular mechanisms in diseases. In particular there is a multidisciplinary collaborative effort to define subsets of monocytes, to study the role of surface enzymes in normal and disordered monocyte function, and to correlate the structure and function of various subsets of lymphocytes. These studies focus on the amyloid diseases and various lymphoid neoplasms. 4) Genetics, development and membrane structure. The main focus of this work is to evaluate the role of genetic factors in resistance to leukemia and to study various surface components of lymphoid cells coded by the major histocompatibility locus that behave as differentiation markers and may play a role in lymphocyte function and cell-cell interaction.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
5P01AR001431-32
Application #
3092300
Study Section
(SRC)
Project Start
1976-01-01
Project End
1989-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
32
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

Rostagno, A A; Frangione, B; Gold, L (1991) Biochemical studies on the interaction of fibronectin with Ig. J Immunol 146:2687-93
Abramson, S B; Leszczynska-Piziak, J; Haines, K et al. (1991) Non-steroidal anti-inflammatory drugs: effects on a GTP binding protein within the neutrophil plasma membrane. Biochem Pharmacol 41:1567-73
Abramson, S B; Cherksey, B; Gude, D et al. (1990) Nonsteroidal antiinflammatory drugs exert differential effects on neutrophil function and plasma membrane viscosity. Studies in human neutrophils and liposomes. Inflammation 14:11-30
Haltia, M; Ghiso, J; Prelli, F et al. (1990) Amyloid in familial amyloidosis, Finnish type, is antigenically and structurally related to gelsolin. Am J Pathol 136:1223-8
Tagliavini, F; Ghiso, J; Timmers, W F et al. (1990) Coexistence of Alzheimer's amyloid precursor protein and amyloid protein in cerebral vessel walls. Lab Invest 62:761-7
Haines, K A; Reibman, J; Callegari, P E et al. (1990) Cocaine and its derivatives blunt neutrophil functions without influencing phosphorylation of a 47-kilodalton component of the reduced nicotinamide-adenine dinucleotide phosphate oxidase. J Immunol 144:4757-64
Ghiso, J; Saball, E; Leoni, J et al. (1990) Binding of cystatin C to C4: the importance of sense-antisense peptides in their interaction. Proc Natl Acad Sci U S A 87:1288-91
Picken, M M; Larrondo-Lillo, M; Coria, F et al. (1990) Distribution of the protease inhibitor alpha 1-antichymotrypsin in cerebral and systemic amyloid. J Neuropathol Exp Neurol 49:41-8
Prelli, F; Levy, E; van Duinen, S G et al. (1990) Expression of a normal and variant Alzheimer's beta-protein gene in amyloid of hereditary cerebral hemorrhage, Dutch type: DNA and protein diagnostic assays. Biochem Biophys Res Commun 170:301-7
Giaccone, G; Verga, L; Finazzi, M et al. (1990) Cerebral preamyloid deposits and congophilic angiopathy in aged dogs. Neurosci Lett 114:178-83

Showing the most recent 10 out of 25 publications