Abstract

This Program Project deals with studies on various aspects of the immune system as they relate to the pathogenesis of the rheumatic diseases. The various projects include studies on the genetic expression, synthesis, and regulation of molecules active in immunopathology. Since most of these projects involve a detailed determination of protein structure, a Core Laboratory has been established to perform amino acid sequencing in an efficient and comprehensive manner on nanamole quantities of proteins. The following Project areas are included: 1. Cell Surface Molecular Chemistry; 2. Complement Biochemistry and Biology; 3. The Immunosuppressive Role of Human Choronic Gonadotrophin; 4. Pathological Immunoglobulins; 5. Characterization of Interleukin I; 6. Neutrophil Proteinases. These projects are interrelated at both conceptual and practical levels, because of our investigation thrusts toward understanding the pathogenesis of rheumatic disease. More importantly, they promise a high level of potential clinical application.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
5P01AR003555-31
Application #
3092310
Study Section
Special Emphasis Panel (SRC)
Project Start
1977-12-01
Project End
1991-02-28
Budget Start
1989-12-01
Budget End
1991-02-28
Support Year
31
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Rundle, C H; Schroeder Jr, H W; Koopman, W J (1998) In situ hybridization analysis of immunoglobulin heavy chain variable gene expression with family specific oligonucleotide probes. J Immunol Methods 218:31-52
Su, X; Zhou, T; Yang, P et al. (1998) Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptor. Arthritis Rheum 41:139-49
Clausen, B E; Bridges Jr, S L; Lavelle, J C et al. (1998) Clonally-related immunoglobulin VH domains and nonrandom use of DH gene segments in rheumatoid arthritis synovium. Mol Med 4:240-57
Fleck, M; Zhou, T; Tatsuta, T et al. (1998) Fas/Fas ligand signaling during gestational T cell development. J Immunol 160:3766-75
Johnson, M L; Keeton, L G; Zhu, Z B et al. (1997) Age-related changes in serum immunoglobulins in patients with familial IgA deficiency and common variable immunodeficiency (CVID). Clin Exp Immunol 108:477-83
Hsu, H C; Zhou, T; Yang, P A et al. (1997) Increased acute-phase response and renal amyloidosis in aged CD2-fas-transgenic mice. J Immunol 158:5988-96
Zhou, T; Fleck, M; Mueller-Ladner, U et al. (1997) Kinetics of Fas-induced apoptosis in thymic organ culture. J Clin Immunol 17:74-84
Cheng, J; Liu, C; Yang, P et al. (1997) Increased lymphocyte apoptosis in Fas ligand transgenic mice. J Immunol 159:674-84
Tatsuta, T; Cheng, J; Mountz, J D (1996) Intracellular IL-1beta is an inhibitor of Fas-mediated apoptosis. J Immunol 157:3949-57
Mountz, J D; Edwards 3rd, C K; Cheng, J et al. (1996) Autoimmunity due to defective Nur77, Fas, and TNF-RI apoptosis. Adv Exp Med Biol 406:241-62

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