Abstract

This is a transgenic and molecular biology core facility to design and synthesize DNA constructs, introduce the constructs into the germ line of mice, design appropriate breeding experiments and hybridization procedures to detect transgenes or specific endogenous DNA sequences, and to provide sufficient numbers of animals under appropriate experimental conditions for individual investigators' use.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
5P01AR038933-13
Application #
6338659
Study Section
Project Start
2000-08-01
Project End
2001-09-27
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
13
Fiscal Year
2000
Total Cost
$156,510
Indirect Cost

  Institution

Name
University of Connecticut
Department
Type
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030

  Publications

Marijanovic, Inga; Kronenberg, Mark S; Erceg Ivkosic, Ivana et al. (2009) Comparison of proliferation and differentiation of calvarial osteoblast cultures derived from Msx2 deficient and wild type mice. Coll Antropol 33:919-24
Zhang, W; Pantschenko, A G; McCarthy, M-B et al. (2007) Bone-targeted overexpression of Bcl-2 increases osteoblast adhesion and differentiation and inhibits mineralization in vitro. Calcif Tissue Int 80:111-22
He, Jianing; Rosen, Clifford J; Adams, Douglas J et al. (2006) Postnatal growth and bone mass in mice with IGF-I haploinsufficiency. Bone 38:826-35
Lengner, Christopher J; Steinman, Heather A; Gagnon, James et al. (2006) Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol 172:909-21
Delahunty, K M; Shultz, K L; Gronowicz, G A et al. (2006) Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition. Endocrinology 147:3915-23
Sher, L B; Harrison, J R; Adams, D J et al. (2006) Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling. Calcif Tissue Int 79:118-25
Jiang, Jin; Lichtler, Alexander C; Gronowicz, Gloria A et al. (2006) Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodeling. Bone 39:494-504
Lee, Sun-Kyeong; Gardner, Amy E; Kalinowski, Judith F et al. (2006) RANKL-stimulated osteoclast-like cell formation in vitro is partially dependent on endogenous interleukin-1 production. Bone 38:678-85
Wang, Liping; Liu, Yaling; Kalajzic, Zana et al. (2005) Heterogeneity of engrafted bone-lining cells after systemic and local transplantation. Blood 106:3650-7
Pantschenko, Alexander G; Zhang, Wenjian; Nahounou, Marcia et al. (2005) Effect of osteoblast-targeted expression of bcl-2 in bone: differential response in male and female mice. J Bone Miner Res 20:1414-29

Showing the most recent 10 out of 94 publications