Abstract

The Core Laboratory will provide individual investigators with cell products and assays which will be needed routinely and which are better performed in a centralized facility. They will also supply the various projects with the in vitro assays for bone resorption and bone formation with which our group has extensive experience over the years. The specific activities of the core will include separation of bulk quantities of cells and assays for bone resorption. The personnel of the Core Laboratory will be highly integrated with personnel from a number of projects in the proposal. Most of the projects proposed have, as one of their components, the use of a bioassay and media harvested from cultured cells. The Core Laboratory would provide these services in an efficient, reproducible and cost saving manner.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
5P01AR039529-06
Application #
3728117
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center San Antonio
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229

  Publications

Xu, S C; Harris, M A; Rubenstein, J L et al. (2001) Bone morphogenetic protein-2 (BMP-2) signaling to the Col2alpha1 gene in chondroblasts requires the homeobox gene Dlx-2. DNA Cell Biol 20:359-65
Ji, X; Chen, D; Xu, C et al. (2000) Patterns of gene expression associated with BMP-2-induced osteoblast and adipocyte differentiation of mesenchymal progenitor cell 3T3-F442A. J Bone Miner Metab 18:132-9
Reddy, S V; Roodman, G D (1998) Control of osteoclast differentiation. Crit Rev Eukaryot Gene Expr 8:1-17
Chen, D; Ji, X; Harris, M A et al. (1998) Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J Cell Biol 142:295-305
Roodman, G D (1998) Osteoclast differentiation and activity. Biochem Soc Trans 26:7-13
Yoneda, T (1998) Cellular and molecular mechanisms of breast and prostate cancer metastasis to bone. Eur J Cancer 34:240-5
Nishimura, R; Moriyama, K; Yasukawa, K et al. (1998) Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells. J Bone Miner Res 13:777-85
Xu, C; Ji, X; Harris, M A et al. (1998) A clonal chondrocytic cell line derived from BMP-2/T antigen-expressing transgenic mouse. In Vitro Cell Dev Biol Anim 34:359-63
Mundy, G R (1997) Growth factors as potential therapeutic agents in osteoporosis. Instr Course Lect 46:495-8
Cody, J D; Singer, F R; Roodman, G D et al. (1997) Genetic linkage of Paget disease of the bone to chromosome 18q. Am J Hum Genet 61:1117-22

Showing the most recent 10 out of 49 publications