The Sample Acquisition Core will provide a centralized efficient mechanism for providing the clinical materials needed for the research protocols of each of the individuals research projects included in this program. The common focus on immunologic mechanisms in rheumatoid arthritis shared by each of the individual projects lends itself well to a unified effort to identify and recruit potential subjects, to handle the blood, synovial fluid, and synovial membrane samples obtained from the subjects, and to apportion them as needed to each of the investigators. The director of the core in consultation with the principal investigators of each of the component projects will establish the criteria for selection of patients with rheumatoid arthritis for entry into this study and will educate the Nurse Clinical Coordinator in identifying appropriate candidates by screening of the medical record. The Nurse Clinical Coordinator will attend the outpatient activities of the Division of Rheumatology and screen medical records to identify those patients meeting entry criteria and register them in a computerized database of potential research candidates. As patients are needed for research, their physician will be contacted for approval and the Nurse Clinical Coordinator or the Core Director will then attempt to recruit the patient for the studies. The Nurse Clinical Coordinator will draw the required blood specimens form those patients who agree to participate and the patient's physician or the Core Director will perform arthrocenteses for those patients donating synovial fluid. The Nurse Clinical Coordinator will process the blood and synovial fluid specimens, contact the individual investigators, and arrange for delivery of the samples to the research laboratories. For those projects requiring correlation between rheumatoid disease activity and research laboratory findings, quantitative joint examinations will be performed by the Nurse Clinical Coordinator and/or the Core Director.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
La Jolla
United States
Zip Code
Alvarez-Garcia, Oscar; Matsuzaki, Tokio; Olmer, Merissa et al. (2017) Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration. J Orthop Res 35:2682-2691
Grogan, Shawn P; Pauli, Chantal; Lotz, Martin K et al. (2017) Relevance of meniscal cell regional phenotype to tissue engineering. Connect Tissue Res 58:259-270
Prakken, Berent J; Roord, Sarah; van Kooten, Peter J S et al. (2002) Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope. Arthritis Rheum 46:1937-46
Prakken, B J; Carson, D A; Albani, S (2001) T cell repertoire formation and molecular mimicry in rheumatoid arthritis. Curr Dir Autoimmun 3:51-63
Yang, Y Y; Fischer, P; Leu, S J et al. (1999) Possible presence of enhancing antibodies in idiopathic thrombocytopenic purpura. Br J Haematol 104:69-80
Chukwuocha, R U; Zhang, B; Lai, C J et al. (1999) Isolation of an IgG monoclonal anti-dnaJ antibody from an immunoglobulin combinatorial library from a patient with rheumatoid arthritis. J Rheumatol 26:1439-45
Bonnin, D; Albani, S (1998) Mucosal modulation of immune responses to heat shock proteins in autoimmune arthritis. Biotherapy 10:213-21
Kohsaka, H; Carson, D A; Miyasaka, N (1998) Formation of peripheral immunoreceptor repertoire for antigens: potential relationship to the pathogenesis of rheumatoid arthritis. Arthritis Rheum 41:1911-8
Lee, D J; Corr, M; Carson, D A (1998) Control of immune responses by gene immunization. Ann Med 30:460-8
Cantwell, M; Hua, T; Pappas, J et al. (1997) Acquired CD40-ligand deficiency in chronic lymphocytic leukemia. Nat Med 3:984-9

Showing the most recent 10 out of 28 publications