Abstract

The proposed program project will develop cutaneous gene therapy for junctional epidermolysis bullosa (JEB) while studying key relevant features of cutaneous biology. The goals of this project focus on further characterizing basement membrane zone proteins in relationship to blistering human skin disease, as well as on cutaneous gene regulation strategies, stem cell biology and gene delivery methods. We shall attempt to develop effective approaches for long term delivery of therapeutic genes to the skin as a foundation for gene therapy for JEB and for systematic application in the treatment of human genetic skin disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
5P01AR044012-02
Application #
2732883
Study Section
Special Emphasis Panel (ZAR1-TLB-B (M1))
Project Start
1997-09-30
Project End
2002-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Dermatology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Vijayakumar, Soundarapandian; Dang, Suparna; Marinkovich, M Peter et al. (2014) Aberrant expression of laminin-332 promotes cell proliferation and cyst growth in ARPKD. Am J Physiol Renal Physiol 306:F640-54
Gao, Jing; DeRouen, Mindy C; Chen, Chih-Hsin et al. (2008) Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev 22:2111-24
Tran, Mark; Rousselle, Patricia; Nokelainen, Pasi et al. (2008) Targeting a tumor-specific laminin domain critical for human carcinogenesis. Cancer Res 68:2885-94
Waterman, Elizabeth A; Sakai, Noriyasu; Nguyen, Ngon T et al. (2007) A laminin-collagen complex drives human epidermal carcinogenesis through phosphoinositol-3-kinase activation. Cancer Res 67:4264-70
Pullar, Christine E; Baier, Brian S; Kariya, Yoshinobu et al. (2006) beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1. Mol Biol Cell 17:4925-35
Li, Jie; Zhou, Lisa; Tran, Hoang T et al. (2006) Overexpression of laminin-8 in human dermal microvascular endothelial cells promotes angiogenesis-related functions. J Invest Dermatol 126:432-40
Gonzalez-Quevedo, Rosa; Shoffer, Marina; Horng, Lily et al. (2005) Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4. J Cell Biol 168:453-63
Yant, Stephen R; Wu, Xiaolin; Huang, Yong et al. (2005) High-resolution genome-wide mapping of transposon integration in mammals. Mol Cell Biol 25:2085-94
Ortiz-Urda, Susana; Garcia, John; Green, Cheryl L et al. (2005) Type VII collagen is required for Ras-driven human epidermal tumorigenesis. Science 307:1773-6
Arbiser, Jack L; Fan, Chun-Yang; Su, Xiaobo et al. (2004) Involvement of p53 and p16 tumor suppressor genes in recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma. J Invest Dermatol 123:788-90

Showing the most recent 10 out of 58 publications