Abstract

The goal of the Mouse Breeding Core is to provide mice and hamsters to Program investigators in a cost-effective and dependable manner. Both control and dystrophic mice and hamsters will be bred to maintain a colony of sufficient size such that ample animals of specified age can be supplied to each of the research projects in this Program. This Core has been in operation for early two years, and has been run by Dr. Clemens during this time. Support has previously been derived from a parent-run foundation, as part of the DMDRC. Setting of priorities of the Core will be done by Dr. Clemens, with the Program Director(Dr. Hoffman) arbitrating any conflicts with regards mouse or hamster requirements. Day-to-day operation of the Core, including distribution of mice and hamsters, will be done by a technician, Ms. Christy Bruton, who has been responsible for the Core to date.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
5P01AR045925-04
Application #
6588789
Study Section
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
4
Fiscal Year
2002
Total Cost
$196,218
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Reay, D P; Bilbao, R; Koppanati, B M et al. (2008) Full-length dystrophin gene transfer to the mdx mouse in utero. Gene Ther 15:531-6
Zhang, Jing-Shi; Liu, Feng; Conwell, Christine C et al. (2006) Mechanistic studies of sequential injection of cationic liposome and plasmid DNA. Mol Ther 13:429-37
Bilbao, Roberto; Reay, Daniel P; Li, Juan et al. (2005) Patterns of gene expression from in utero delivery of adenoviral-associated vector serotype 1. Hum Gene Ther 16:678-84
Conwell, Christine C; Huang, Leaf (2005) Recent advances in non-viral gene delivery. Adv Genet 53:3-18
Deasy, B M; Gharaibeh, B M; Pollett, J B et al. (2005) Long-term self-renewal of postnatal muscle-derived stem cells. Mol Biol Cell 16:3323-33
Bilbao, R; Reay, D P; Wu, E et al. (2005) Comparison of high-capacity and first-generation adenoviral vector gene delivery to murine muscle in utero. Gene Ther 12:39-47
Kimura, Shigemi; Ikezawa, Makoto; Cao, Baohong et al. (2004) Ex vivo gene transfer to mature skeletal muscle by using adenovirus helper cells. J Gene Med 6:155-65
Cao, B; Bruder, J; Kovesdi, I et al. (2004) Muscle stem cells can act as antigen-presenting cells: implication for gene therapy. Gene Ther 11:1321-30
Bilbao, Roberto; Reay, Daniel P; Koppanati, Bhanu M et al. (2004) Biocompatibility of adenoviral vectors in poly(vinyl chloride) tubing catheters with presence or absence of plasticizer di-2-ethylhexyl phthalate. J Biomed Mater Res A 69:91-6
Li, Zhenhua; Huang, Leaf (2004) Sustained delivery and expression of plasmid DNA based on biodegradable polyester, poly(D,L-lactide-co-4-hydroxy-L-proline). J Control Release 98:437-46

Showing the most recent 10 out of 52 publications