The overarching main objective of this Program Project is to understand the mechanisms through which autoantigen/autoantibody complexes contribute to the initiation and/or maintainence of systemic lupus erythematosus. The various projects in the Program will rely, in part, on a number of antigens, antibodies and viral vectors to carry out the proposed specific aims. The successful completion of these aims has been and will continue to be enhanced by the availability of a set of highly defined, quality controlled reagents that will be produced by this Core.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
5P01AR050256-09
Application #
8290054
Study Section
Special Emphasis Panel (ZAR1)
Project Start
2011-07-01
Project End
2014-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
9
Fiscal Year
2011
Total Cost
$3,164
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Type
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Pawaria, Sudesh; Sharma, Shruti; Baum, Rebecca et al. (2017) Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent? J Leukoc Biol 101:121-126
Sindhava, Vishal J; Oropallo, Michael A; Moody, Krishna et al. (2017) A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens. J Clin Invest 127:1651-1663
Baum, Rebecca; Sharma, Shruti; Organ, Jason M et al. (2017) STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice. Arthritis Rheumatol 69:460-471
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Giles, Josephine R; Neves, Adriana Turqueti; Marshak-Rothstein, Ann et al. (2017) Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation. JCI Insight 2:e90870
Bossaller, Lukas; Christ, Anette; Pelka, Karin et al. (2016) TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus. J Immunol 197:1044-53
Garcia-Martinez, Irma; Santoro, Nicola; Chen, Yonglin et al. (2016) Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9. J Clin Invest 126:859-64
Baum, Rebecca; NĂ¼ndel, Kerstin; Pawaria, Sudesh et al. (2016) Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice. J Immunol 196:1348-54
Moody, Krishna L; Uccellini, Melissa B; Avalos, Ana M et al. (2016) Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells. Methods Mol Biol 1390:249-72
Pawaria, Sudesh; Moody, Krishna L; Busto, Patricia et al. (2015) An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual. Clin Exp Rheumatol 33:S70-3

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