Principal Investigator / ProgramDirector (Last, first, middle) ? Ziskin, Marvin C. Project 2 MILLIMETER WAVE ANDDRUG INDUCED MODULATION OF THE IMMUNE SYSTEM Abstract Millimeter waves (MWs) are widely used for the treatment of various diseases in the former Soviet Union countries. The three most common frequencies employed in millimeter wave therapy (MWT) are 42.2, 53.6 and 61.2 GHz. MWT can be used alone or in combination with other treatment methods. As an adjunct therapy, it has been reported to reduce the toxic side effects of chemo- and radiation therapy in the treatment of cancer. However, the mechanisms involved in this protection are not known. The overall goal of our project is to test the validity of Soviet claims and to further understand the immune mechanisms involved in MWT particularly when it is used in combination with chemotherapy. Our preliminary studies suggest that immune functions can be modulated by MW irradiation. In the proposed studies we will further investigate how immunomodulation by MWs can occur and how it can be used to improve its efficacy in reducing the toxicity of chemo- therapy.
The specific aims of this project are to determine (1) how MWs protect lymphocytes from drug induced toxicity, (2) how millimeter waves reduce tumor metastasis (3) if MWs restore compromised functions by altering gene expression, and (4) the physical factors underlying the effectiveness of MW therapy. The proposed studies are designed to understand the basic immune mechanisms of MWT. Besides, they will provide guidance for clinical applications because modulation of the immune system, potentiation or suppression, is being used for the treatment and management of many diseases.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Research Program Projects (P01)
Project #
5P01AT002025-04
Application #
7676189
Study Section
Special Emphasis Panel (ZAT1)
Project Start
Project End
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
4
Fiscal Year
2008
Total Cost
$489,839
Indirect Cost
Name
Temple University
Department
Type
DUNS #
057123192
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Ziskin, Marvin C (2013) Millimeter waves: acoustic and electromagnetic. Bioelectromagnetics 34:3-14
Logani, Mahendra K; Alekseev, Stanislav; Bhopale, Mahendra K et al. (2012) Effect of millimeter waves and cyclophosphamide on cytokine regulation. Immunopharmacol Immunotoxicol 34:107-12
Alekseev, Stanislav I; Ziskin, Marvin C (2011) Enhanced absorption of millimeter wave energy in murine subcutaneous blood vessels. Bioelectromagnetics 32:423-33
Egot-Lemaire, St├ęphane J-P; Ziskin, Marvin C (2011) Dielectric properties of human skin at an acupuncture point in the 50-75?GHz frequency range: a pilot study. Bioelectromagnetics 32:360-6
Alekseev, S I; Ziskin, M S; Fesenko, E E (2011) [Problems of using a thermocouple for measurements of skin temperature rise during the exposure to millimeter waves]. Biofizika 56:561-5
Alekseev, Stanislav I; Fesenko, Evgeny E; Ziskin, Marvin C (2010) Enhanced absorption of microwaves within cylindrical holes in Teflon film. IEEE Trans Biomed Eng 57:2517-24
Alekseev, Stanislav I; Gordiienko, Oleg V; Radzievsky, Alexander A et al. (2010) Millimeter wave effects on electrical responses of the sural nerve in vivo. Bioelectromagnetics 31:180-90
Alekseev, Stanislav I; Ziskin, Marvin C (2009) Millimeter-wave absorption by cutaneous blood vessels: a computational study. IEEE Trans Biomed Eng 56:2380-8
Nicolaz, Christophe Nicolas; Zhadobov, Maxim; Desmots, Fabienne et al. (2009) Study of narrow band millimeter-wave potential interactions with endoplasmic reticulum stress sensor genes. Bioelectromagnetics 30:365-73
Alekseev, S I; Ziskin, M C (2009) Influence of blood flow and millimeter wave exposure on skin temperature in different thermal models. Bioelectromagnetics 30:52-8

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