Metal Chelators and thiols in Endothelial Function and CVD

Frei, Balz B.

Abstract

P01 AT002034 (Frei) 09/30/03-05/31/08 NIH/NCCAM Center of Excellence for Research on Complementary and Alternative Medicine Antioxidant Therapies (CERCAT) The major goals of this program project grant are to determine the roles of oxidative and nitrative stress in animal models of atherosclerosis, Lou Gehrig's disease, and aging, and the protective effects of lipoic acid and metal chelation therapy. The major goals of Project 1 (Metal Chelators and Thiols in Endothelial Function and CVD) are to understand the mechanisms by which thiol compounds and transition metals affect redoxsensitive cellular signaling and transcription factor activation;and to investigate in animal models of inflammation and atherosclerosis whether lipoic acid and metal chelators exert anti-inflammatory and antiatherosclerotic effects by inhibiting cellular adhesion molecule expression. Roles: Program Director, Project 1 Leader (Metal Chelators and Thiols in Endothelial Function and CVD), and Administrative Core Director

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Complementary & Alternative Medicine (NCCAM)
• Type: Research Program Projects (P01)
• Project #: 5P01AT002034-08
• Application #: 8075106
• Study Section: Special Emphasis Panel (ZAT1)
• Budget Start: 2010-06-01
• Budget End: 2011-05-31
• Support Year: 8
• Fiscal Year: 2010
• Total Cost: $468,329

Institution

• Name: Oregon State University
• DUNS #: 053599908
• City: Corvallis
• State: OR
• Country: United States
• Zip Code: 97339

Publications

Williams, Jared R; Trias, Emiliano; Beilby, Pamela R et al. (2016) Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD. Neurobiol Dis 89:1-9

Thomas, Nicholas O; Shay, Kate P; Kelley, Amanda R et al. (2016) Glutathione maintenance mitigates age-related susceptibility to redox cycling agents. Redox Biol 10:45-52

Smith, Eric J; Shay, Kate P; Thomas, Nicholas O et al. (2015) Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a. Free Radic Biol Med 89:1184-91

Zhang, Wei-Jian; Frei, Balz (2015) Astragaloside IV inhibits NF- ? B activation and inflammatory gene expression in LPS-treated mice. Mediators Inflamm 2015:274314

Keith, Dove; Finlay, Liam; Butler, Judy et al. (2014) Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age. Biochem Biophys Res Commun 450:324-9

Wei, Hao; Zhang, Wei-Jian; Leboeuf, Renee et al. (2014) Copper induces--and copper chelation by tetrathiomolybdate inhibits--endothelial activation in vitro. Redox Rep 19:40-8

Rhoads, Timothy W; Williams, Jared R; Lopez, Nathan I et al. (2013) Using theoretical protein isotopic distributions to parse small-mass-difference post-translational modifications via mass spectrometry. J Am Soc Mass Spectrom 24:115-24

Franco, Maria Clara; Ye, Yaozu; Refakis, Christian A et al. (2013) Nitration of Hsp90 induces cell death. Proc Natl Acad Sci U S A 110:E1102-11

Viera, Liliana; Radmilovich, Milka; Vargas, Marcelo R et al. (2013) Temporal patterns of tyrosine nitration in embryo heart development. Free Radic Biol Med 55:101-8

Gandelman, Mandi; Levy, Mark; Cassina, Patricia et al. (2013) P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway. J Neurochem 126:382-8