The UCLA Center for Excellence in Pancreatic Diseases constitutes a highly collaborative, multidisciplinary research program designed to make a significant impact on the investigation of complimentary and alternative medicine in the prevention and therapy of pancreatic diseases. Biological mechanisms of action of botanicals and dietary supplements on pancreatic diseases and characterization of metabolic phenotypes? in response to specific phytonutrients can form the rationale for biologically-based practices in the prevention? and treatment of pancreatic diseases. Our Center includes expertise from the UCLA campus, LA BioMed? Research Institute at Harbor-UCLA Medical Center, and VA Greater Los Angeles Healthcare System-West? Los Angeles (VAGLAHS-WLA). The Center is led by experienced pancreatic disease researchers who have? organized investigative teams to develop highly interactive and synergistic research programs. Our goal is? to study the phytonutrient mechanism of action in both inflammatory and proliferative diseases of the? pancreas in which we will use molecular biology and metabolomic technology to investigate altered cellular? function. Characterization of metabolic phenotypes in response to specific phytonutrients can be measured? by tracer metabolomics. These scientific programs will investigate the mechanisms of action of? phytonutrients in both inflammatory and proliferative diseases of the pancreas utilizing both molecular? biology tools and metabolomics technology. The projects will focus on: Project 1 - the effects of? phytochemicals and metabolism in pancreatic diseases, Project 2 - role of polyphenols in regulating lipid? inflammatory process in pancreatic cancer, and Project 3 - the effects of flavonoids on pancreatic? carcinogenesis and angiogenesis. The projects will utilize our shared core resources including the? Administrative Core, Animal Model Core, Phytonutrient Core, and Metabolomics Core. The Administrative? Core includes a Biostatistics Sub-Core to provide biostatistical support to all the research projects and core? functions, as well as the management of research and shared data functions of the Center. We also plan to? select an External Advisory Board comprised of nationally and internationally recognized translational? pancreatic disease researchers. The UCLA Center for Excellence is designed for maximum integration and? synergy of research of key investigators who have been collaborating over the years so that the Center can? be focused on the most promising investigations with the greatest NCCAM translational potential.

National Institute of Health (NIH)
National Center for Complementary & Alternative Medicine (NCCAM)
Research Program Projects (P01)
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Study Section
Special Emphasis Panel (ZAT1-SM (07))
Program Officer
Sorkin, Barbara C
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University of California Los Angeles
Internal Medicine/Medicine
Schools of Medicine
Los Angeles
United States
Zip Code
Yang, Qing; Fung, Wing K; Li, Gang (2018) Sample size determination for jointly testing a cause-specific hazard and the all-cause hazard in the presence of competing risks. Stat Med 37:1389-1401
Wang, Hong; Chen, Xiaolin; Li, Gang (2018) Survival Forests with R-Squared Splitting Rules. J Comput Biol 25:388-395
Somlyai, Gábor; Collins, T Que; Meuillet, Emmanuelle J et al. (2017) Structural homologies between phenformin, lipitor and gleevec aim the same metabolic oncotarget in leukemia and melanoma. Oncotarget 8:50187-50192
Birtolo, Chiara; Go, Vay Liang W; Ptasznik, Andrzej et al. (2016) Phosphatidylinositol 3-Kinase: A Link Between Inflammation and Pancreatic Cancer. Pancreas 45:21-31
Pham, Hung; Hui, Hongxiang; Morvaridi, Susan et al. (2016) A bitter pill for type 2 diabetes? The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cells. Biochem Biophys Res Commun 475:295-300
Boros, László G; D'Agostino, Dominic P; Katz, Howard E et al. (2016) Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle. Med Hypotheses 87:69-74
Varma, Vijayalakshmi; Boros, László G; Nolen, Greg T et al. (2015) Fructose Alters Intermediary Metabolism of Glucose in Human Adipocytes and Diverts Glucose to Serine Oxidation in the One-Carbon Cycle Energy Producing Pathway. Metabolites 5:364-85
Vaitheesvaran, B; Xu, J; Yee, J et al. (2015) The Warburg effect: a balance of flux analysis. Metabolomics 11:787-796
Gregson, A L; Wang, X; Injean, P et al. (2015) Staphylococcus via an interaction with the ELR+ CXC chemokine ENA-78 is associated with BOS. Am J Transplant 15:792-9
Lu, Qing-Yi; Zhang, Lifeng; Yee, Jennifer K et al. (2015) Metabolic Consequences of LDHA inhibition by Epigallocatechin Gallate and Oxamate in MIA PaCa-2 Pancreatic Cancer Cells. Metabolomics 11:71-80

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