Abstract

The General Laboratory facility Core will breed and maintain all Ncr nu/nu mice in the Department of Experimental Radiation Oncology specific pathogen free (virus negative) mouse colony for all in vivo experiments. This core will also provide for the production of routine histology/immunohistochemistry of human tumor xenografts. Lastly, it will provide for the design and manufacture of custom jigs for irradiation of mice and perform dosimetry for all proposed radiation experiments.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA006294-44
Application #
7634547
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
44
Fiscal Year
2008
Total Cost
$291,772
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Edmondson, Elijah F; Hunter, Nancy R; Weil, Michael M et al. (2015) Tumor Induction in Mice After Localized Single- or Fractionated-Dose Irradiation: Differences in Tumor Histotype and Genetic Susceptibility Based on Dose Scheduling. Int J Radiat Oncol Biol Phys 92:829-36
Neskey, David M; Osman, Abdullah A; Ow, Thomas J et al. (2015) Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer. Cancer Res 75:1527-36
Keck, Michaela K; Zuo, Zhixiang; Khattri, Arun et al. (2015) Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes. Clin Cancer Res 21:870-81
Alsbeih, Ghazi; Brock, Williams; Story, Michael (2014) Misrepair of DNA double-strand breaks in patient with unidentified chromosomal fragility syndrome and family history of radiosensitivity. Int J Radiat Biol 90:53-9
Komaki, Ritsuko; Paulus, Rebecca; Blumenschein Jr, George R et al. (2014) EGFR expression and survival in patients given cetuximab and chemoradiation for stage III non-small cell lung cancer: a secondary analysis of RTOG 0324. Radiother Oncol 112:30-6
Cortez, Maria Angelica; Valdecanas, David; Zhang, Xiaochun et al. (2014) Therapeutic delivery of miR-200c enhances radiosensitivity in lung cancer. Mol Ther 22:1494-1503
Bhardwaj, Vikas; Cascone, Tina; Cortez, Maria Angelica et al. (2013) Modulation of c-Met signaling and cellular sensitivity to radiation: potential implications for therapy. Cancer 119:1768-75
Raju, Uma; Riesterer, Oliver; Wang, Zhi-Qiang et al. (2012) Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways. Radiother Oncol 105:241-9
Thariat, Juliette; Ang, K Kian; Allen, Pamela K et al. (2012) Prediction of neck dissection requirement after definitive radiotherapy for head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys 82:e367-74
Skinner, Heath D; Sandulache, Vlad C; Ow, Thomas J et al. (2012) TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res 18:290-300

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