Abstract

)The general goal of this program is directed at gaining a deeper understanding of the molecular mechanisms which are the basis for the normal tissue late effects which are observed in the lung following radiation. Previous CERRIS programs have led to the paradigm of radiation late effects being dependent upon the """"""""conversation"""""""" which takes place between a number of injured cells, rather than the classic concept of a single target cell. In pursuit of this goal, they mean to further define the conversation, which they have hypothesized as a """"""""cytokine cascade"""""""", in terms of the spatial and temporal release of proinflammatory and profibrotic cytokines and growth factors, and their genetic context. Expansion of this paradigm has led them to postulate the role of the immune system in the development of late tissue effects and this will be explored in more detail. Modulation of the cytokine cascade(s) and/or the immune system will be investigated as a means of both elucidating the roles of specific cytokines, as well as suggesting routes of amelioration.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA011051-29
Application #
6563658
Study Section
Project Start
2002-02-01
Project End
2003-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
29
Fiscal Year
2002
Total Cost
$157,506
Indirect Cost

  Institution

Name
University of Rochester
Department
Type
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Groves, Angela M; Johnston, Carl J; Misra, Ravi S et al. (2015) Whole-Lung Irradiation Results in Pulmonary Macrophage Alterations that are Subpopulation and Strain Specific. Radiat Res 184:639-49
Okunieff, Paul; Xu, Jianhua; Hu, Dongping et al. (2006) Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines. Int J Radiat Oncol Biol Phys 65:890-8
Moore, Amy H; Olschowka, John A; Williams, Jacqueline P et al. (2005) Regulation of prostaglandin E2 synthesis after brain irradiation. Int J Radiat Oncol Biol Phys 62:267-72
Okunieff, Paul; Cornelison, Terri; Mester, Marcelo et al. (2005) Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors. Int J Radiat Oncol Biol Phys 62:273-8
Chen, Yuhchyau; Hyrien, Ollivier; Williams, Jacqueline et al. (2005) Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis. Int J Radiat Oncol Biol Phys 62:260-6
Moore, Amy H; Olschowka, John A; Williams, Jacqueline P et al. (2004) Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain. Radiat Res 161:153-60
Ding, Ivan; Liu, Weimin; Sun, Jianzhong et al. (2003) FGF1 and VEGF mediated angiogenesis in KHT tumor-bearing mice. Adv Exp Med Biol 530:603-9
Liang, Li; Hu, Dongping; Liu, Weimin et al. (2003) Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor. Am J Clin Oncol 26:S114-21
Williams, Jacqueline; Chen, Yuhchyau; Rubin, Philip et al. (2003) The biological basis of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol 13:182-8
Chen, Yuhchyau; Williams, Jacqueline; Ding, Ivan et al. (2002) Radiation pneumonitis and early circulatory cytokine markers. Semin Radiat Oncol 12:26-33

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