Abstract

This project seeks support for multidisciplinary clinical research projects dealing with proposals for new methods of diagnosis and treatment of cancer. The leukemia-lymphoma program has projects in autologous bone marrow transplantation, childhood ALL, studies of newly described morphologic particles, research on lymphoproliferative and myeloproliferative disorders, leukemia immunology, platelet antigens, and biochemical pharmacologic studies of new lipid soluble folate antagonists. Additional programs are described in urologic oncology, which include a range of projects from ultrastructure, culture of human cells and clinical chemotherapy through tometabolic studies of new findings of tumor induced osteomalacia, and prognostic factors in prostatic cancer. Interdisciplinary programs in lung cancer, head and neck cancer, breast cancer, malignant melanoma, and brain tumors are also presented in this application. The central feature of this request is that we have a newly constructed facility in which multidisciplinary research can be conducted and which provides the optimal conditions for education and patient care and enables the collection of research materials for laboratory investigations. The clinical faculty has been greatly expanded and the scope of research increased accordingly.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA011265-16
Application #
3092546
Study Section
Clinical Cancer Program Project Review Committee (CCP)
Project Start
1977-03-01
Project End
1986-11-30
Budget Start
1985-02-01
Budget End
1986-11-30
Support Year
16
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Burkes Jr, E J; Lyles, K W; Dolan, E A et al. (1991) Dental lesions in tumoral calcinosis. J Oral Pathol Med 20:222-7
Soper, J T; Cox, E B; Budwit-Novotny, D et al. (1987) Histologic composition of endometrial carcinomas analyzed for steroid receptor content. Am J Obstet Gynecol 157:26-7
Mutch, D G; Soper, J T; Budwit-Novotny, D A et al. (1987) Endometrial adenocarcinoma estrogen receptor content: association of clinicopathologic features with immunohistochemical analysis compared with standard biochemical methods. Am J Obstet Gynecol 157:924-31
Flowers, J L; Seigler, H F; McCarty Sr, K S et al. (1987) Absence of estrogen receptor in human melanoma as evaluated by a monoclonal antiestrogen receptor antibody. Arch Dermatol 123:764-5
Burton, G V; Flowers, J L; Cox, E B et al. (1987) Estrogen receptor determination by monoclonal antibody in fine needle aspiration breast cancer cytologies: a marker of hormone response. Breast Cancer Res Treat 10:287-91
Palker, T J; Scearce, R M; Copeland, T D et al. (1986) C-terminal region of human T cell lymphotropic virus type I (HTLVI) p19 core protein is immunogenic in humans and contains an HTLVI-specific epitope. J Immunol 136:2393-7
McCarty Jr, K S; Szabo, E; Flowers, J L et al. (1986) Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors. Cancer Res 46:4244s-4248s
Budwit-Novotny, D A; McCarty, K S; Cox, E B et al. (1986) Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal antibody. Cancer Res 46:5419-25
Flowers, J L; Burton, G V; Cox, E B et al. (1986) Use of monoclonal antiestrogen receptor antibody to evaluate estrogen receptor content in fine needle aspiration breast biopsies. Ann Surg 203:250-4
McCarty Jr, K S; Miller, L S; Cox, E B et al. (1985) Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Arch Pathol Lab Med 109:716-21

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